O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management?

Table 4 Univariate association (linear regression and Student's t-test) between study variables and ICU and postoperative hospital lengths of stay^a

	Statistical analysis per variable
Variables	β coefficient	Constant	P value
ICU length of stay (days)
Nadir DO₂ (mL/minute/m²)	- 0.020	8.532	0.014
Peak VCO₂ (mL/minute/m²)	0.034	1.297	0.355
Nadir DO₂/VCO₂ ratio	- 0.458	5.703	0.136
Postoperative hospital length of stay (days)
Factor	β coefficient	Constant	P value
Nadir DO₂ (mL/minute/m²)	- 0.055	29.39	0.001
Peak VCO₂ (mL/minute/m²)	0.001	14.15	0.996
Nadir DO₂/VCO₂ ratio	- 0.516	17.02	0.428
	Statistical analysis per cutoff value
	Nadir DO₂ < 262 mL/minute/m²	Nadir DO₂ ≥262 mL/minute/m²	P value
ICU length of stay (days)	4.2 ± 8.7	2.5 ± 4.4	0.019
Postoperative hospital length of stay (days)	17.6 ± 14.1	12.4 ± 12.1	0.001
	Nadir DO₂/VCO₂ ratio < 5.3	Nadir DO₂/VCO₂ ratio ≥5.3	P value
ICU length of stay length of stay (days)	3.4 ± 6.9	2.9 ± 5.6	0.476
Postoperative hospital length of stay (days)	15.3 ± 13.2	13.4 ± 12.6	0.198

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