| |
Model 0 (R2 = 0.42)
|
Model 1 (R2 = 0.63)
|
Model 2 (R2 = 0.43)
|
Model 3(R2 = 0.50)
|
|---|
|
Risk factors and biomarkers
|
Regression coefficient (B) (SE)
|
P value
|
Regression coefficient (B) (SE)
|
P value
|
Regression coefficient (B) (SE)
|
P value
|
Regression coefficient (B) (SE)
|
P value
|
|---|
|
Age, years
|
-0.2 (0.1)
|
0.015
|
-0.2 (0.1)
|
0.06
|
-0.1 (0.1)
|
0.06
|
-0.2 (0.1)
|
0.036
|
|
LVEF <35%
|
-2.9 (1.1)
|
0.009
|
-4.1 (1.6)
|
0.008
|
-2.7 (1.1)
|
0.011
|
-3.0 (1.2)
|
0.01
|
|
COPD
|
-2.2 (1.0)
|
0.036
|
-2.4 (1.3)
|
0.06
|
-2.0 (1.0)
|
0.044
|
-2.5 (1.1)
|
0.026
|
|
Log urine hepcidin/urine creatinine, ng/mg
| | |
2.9 (1.1)
|
0.011
| | | | |
|
Log urine hepcidin, ng/mL
| | | | |
1.2 (0.7)
|
0.09
| | |
|
Log plasma hepcidin, ng/mL
| | | | | | |
2.7 (2.5)
|
0.56
|
- aAKI, acute kidney injury; CPB, cardiopulmonary bypass; LVEF, left ventricular ejection fraction; COPD, chronic obstructive pulmonary disease; SE, standard error. Variables tested on univariate relation with incidence of acute kidney injury (AKI) included all variables displayed in Table 1, type and duration of surgery and renal biomarkers at six hours after start of CPB. Multivariate logistic regression analysis included relevant variables for (no) AKI with univariate P value <0.1 (age, atrial fibrillation, LVEF <35%, COPD and peripheral vascular disease). Variables were presented in model 0 if their multivariate P value was <0.05 (age, LVEF <35% and COPD). We included each biomarker one after another (models 1 through 3) into multivariate regression analysis to exclude interaction.
