All patients | Excluding patients with preoperative CKD | |||||
---|---|---|---|---|---|---|
Hepcidin index | No AKI ( n = 91) | AKI ( n = 9) | P value | No AKI ( n = 69) | AKI ( n = 5) | P value |
Urine hepcidin/urine creatinine, ng/mg | ||||||
Baseline | 308 (122 to 583) | 120 (34 to 295) | 0.07 | 309 (143 to 570) | 164 (100 to 633) | 0.6 |
6 hours after CPB start | 5,175 (2,086 to 9,539) | 1,229 (314 to 2,379) | <0.001 | 5,402 (2,100 to 9,300) | 1,400 (639 to 2,379) | 0.009 |
24 hours after CPB startb | 3,255 (1,576 to 6,652) | 1,345 (537 to 3,583) | 0.07 | 3,143 (1,798 to 6,585) | 1,345 (971 to 3,362) | 0.06 |
Friedman test | <0.001 | 0.005 | <0.001 | 0.11 | ||
Urine creatinine, mg/mL | ||||||
Baseline | 1.14 (0.57 to 1.74) | 0.92 (0.51 to 1.83) | 0.52 | 1.28 (0.60 to 1.96) | 1.66 (0.78 to 2.10) | 0.71 |
6 hours after CPB start | 0.19 (0.10 to 0.28) | 0.21 (0.10 to 0.30) | 0.84 | 0.19 (0.11 to 0.28) | 0.21 (0.12 to 0.30) | 0.97 |
24 hours after CPB startb | 0.46 (0.24 to 0.71) | 0.22 (0.12 to 0.29) | 0.008 | 0.52 (0.29 to 0.73) | 0.22 (0.18 to 0.37) | 0.022 |
Friedman test | <0.001 | 0.03 | <0.001 | 0.17 | ||
Urine/plasma hepcidin ratio | ||||||
Baseline | 2.6 (1.2 to 4.9) | 1.1 (0.2 to 5.6) | 0.18 | 2.8 (1.2 to 4.8) | 4.6 (1.6 to 8.4) | 0.41 |
6 hours after CPB start | 3.1 (1.5 to 5.3) | 1.0 (0.2 to 3.1) | 0.047 | 3.6 (1.9 to 5.9) | 3.0 (1.0 to 46.7) | 0.59 |
24 hours after CPB startb | 6.9 (2.0 to 13.3) | 1.2 (0.6 to 2.4) | 0.011 | 8.2 (3.8 to 15.1) | 2.3 (0.8 to 11.6) | 0.11 |
Friedman test | <0.001 | 0.69 | <0.001 | 0.74 | ||
Fractional hepcidin excretion, % | ||||||
Baseline | 2.4 (1.5 to 4.1) | 1.7 (0.7 to 2.5) | 0.17 | 2.3 (1.5 to 2.9) | 2.5 (1.8 to 4.7) | 0.58 |
6 hours after CPB start | 22.1 (12.2 to 30.0) | 8.3 (1.7 to 19.5) | 0.005 | 22.0 (15.1 to 30.5) | 16.3 (3.6 to 22.5) | 0.19 |
24 hours after CPB startb | 14.7 (9.5 to 25.2) | 8.1 (4.5 to 46.5) | 0.35 | 15.3 (9.9 to 25.2) | 8.1 (5.1 to 55.7) | 0.6 |
Friedman test | <0.001 | 0.021 | <0.001 | 0.47 |