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Table 2 Characteristics of phase-dependent outcome and microbiological diagnosis

From: The late phase of sepsis is characterized by an increased microbiological burden and death rate

phases in relation to diagnosis

phase 0

phase I

phase II

phase III

days prior to diagnosis or during sepsis

Day -10 to Day -1

Day 1 to Day 5

Day 6 to Day 15

Day 16 to Day 150

# of patients alive at onset of phase, #

999

999

886

791

# of non survivors during phase, #

 

113

95

100

relative # of non survivors wrt all non survivors, # (%)

 

36.7 (113/308)

30.8 (95/308)

32.5 (100/308)

relative numbers of non survivors during phase, # (%)

 

11.3 (113/999)

10.7 (95/886)

12.6 (100/791)

# of drawn bc during phase, #

250

882

461

524

relative # of bc per patient alive, # (%)

25.0 (250/999)§

88.3 (882/999)§

52 (461/886)§

66.2 (524/791)§

# of all positive bc during phase, #

49

173

96

146

relative # of positive bc during phase, # (%)

19.6 (49/250)

19.6 (173/882)*

20.8 (96/461)

27.9 (146/524)*

# of positive bc without CNS during phase, #

24

131

52

80

relative # of positive bc without CNS during phase, # (%)

9.6 (24/250)

14.9 (131/882)*

11.3 (52/461)

15.3 (80/524)*

  1. Outcome of patients enrolled (n = 999) with severe sepsis or septic shock is shown corresponding to the distinct phases as defined in Figure 1, starting with phase 0 including a period of 10 days prior to diagnosis of sepsis up to the end of phase III at Day 150. Also, the absolute numbers of drawn blood culture samples, the rate of blood culture samples per number of patients, the rate of all positive blood cultures (including CNS) and the rate of positive blood cultures without CNS are presented. CNS, Coagulase negative staphylococci; §, indicates statistically significant difference between all phases (P ≤ 0.05; χ2 test); *, indicates statistically significant difference compared to phase 0 and II (P ≤ 0.05; χ2 test); #, absolute numbers; %, relative number; bc, blood cultures; wrt, with respect to.