Figure 6

Light photomicrographs of rabbit lungs in various conditions. (a) Lung from a spontaneously breathing (SB) animal. (b) Rabbit lung after 32-hour mild-stretch mechanical ventilation (MV). (c) Lung from a SB animal following tracheal instillation of the synthetic bacterial lipopeptide (BLP), Pam₃CSK₄, and sacrificed 8 hours later. (d) Lung from an animal submitted to 24-hour mild-stretch MV followed by tracheal instillation of BLP and sacrifice 8 hours later. The main abnormalities were septal thickening and inflammatory cell infiltration in rabbits submitted to MV, increased by the presence of BLP. Representative fields, original magnification, x10; hematoxylin and eosin stain.