Skip to main content

Table 1 Characteristics of the patient cohorts

From: Mild hypoglycemia is independently associated with increased mortality in the critically ill

  ALL ST NL-L NL-S GL-C GL-IIT
Demographics and outcomes       
Number 6,240 3,263 1,098 965 460 454
Age 68 (54 to 78) 68 (53 to 80) 69 (57 to 78) 68 (56 to 78) 65 (53 to 74) 65 (51 to 74)
DM (%) 20.4 20.5 N/A N/A 22.6 17.2
Diagnostic category (%)       
Medical 55.2 54.1 64.1 63.2 39.9 40.4
Surgical/Trauma 44.8 45.9 35.9 36.8 60.1 59.6
Mechanical ventilation (%) 45.8 35.4 N/A N/A 84.2 82.0
ICU LOS 2.5 (1.1 to 5.7) 1.5 (0.9 to 3.1) 3.0 (1.8 to 6.9) 3.0 (1.7 to 6.3) 6.0 (3.0 to 13.0) 6.0 (3.0 to 12.5)
APACHE II score 16 (11 to 22) 14 (10 to 21) 19.7 (8.2) 19.4 (8.3) 15 (11 to 21) 15 (11 to 21)
Mortality (%) 19.2 14.2 27.5 26.0 17.8 22.9
Glucose control parameters       
Number of BG measurements per patient 18 (9 to 47) 15 (8 to 34) 17 (7 to 38) 29 (12 to 69) 29 (12 to 74) 37 (15 to 93)
Number of BG measurements per day* 8.7 (5.7 to 10.5) 9.3 (8.0 to 11.3) 5.1 (3.6 to 7.6) 9.8 (6.8 to 12.1) 4.5 (3.2 to 6.7) 5.6 (3.8 to 9.0)
Mean (mg/dL) 124.4 (112.2 to 140.7) 124.0 (112.0 to 138.0) 127.7 (116.4 to 145.0) 117.9 (107.0 to 137.0) 146.3 (128.1 to 164.6) 118.5 (109.3 to 130.3)
CV (%) 23.8 (16.7 to 32.6) 21.0 (14.8 to 28.5) 26.9 (18.8 to 35.2) 31.8 (23.8 to 40.8) 20.7 (15.4 to 26.2) 26.2 (20.3 to 33.1)
SD (mg/dL) 29.5 (20.0 to 42.6) 25.9 (17.7 to 37.5) 33.8 (23.6 to 49.4) 37.1 (27.3 to 50.3) 29.3 (19.9 to 41.7) 30.5 (22.7 to 42.1)
Percentage of patients with hypoglycemia       
< 40 mg/dL 6.7 2.9 8.8 18.1 2.4 9.5
40 to 54 mg/dL 12.6 8.4 13.6 25.2 3.9 23.1
55 to 69 mg/dL 17.7 14.9 19.3 21.6 11.5 31.3
< 70 mg/dL 37.0 26.2 41.7 64.9 17.8 63.9
  1. APACHE II, Acute Physiology and Chronic Health Evaluation II disease classification system; BG, blood glucose; CV, coefficient of variation; DM, diabetes mellitus; GL-C, patients in the control arm of the GLUCONTROL trial; GL-IIT, patients in the intervention arm of the GLUCONTROL trial; LOS, length of stay (days); NL-L, Netherlands "loose" cohort; NL-S, Netherlands "strict" cohort; SD, standard deviation; ST, Stamford cohort.
  2. *Calculated as (mean number of BG tests/mean ICU LOS). Data expressed as median (interquartile range), or percentages