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Table 1 Characteristics of the patient cohorts

From: Mild hypoglycemia is independently associated with increased mortality in the critically ill

 

ALL

ST

NL-L

NL-S

GL-C

GL-IIT

Demographics and outcomes

      

Number

6,240

3,263

1,098

965

460

454

Age

68 (54 to 78)

68 (53 to 80)

69 (57 to 78)

68 (56 to 78)

65 (53 to 74)

65 (51 to 74)

DM (%)

20.4

20.5

N/A

N/A

22.6

17.2

Diagnostic category (%)

      

Medical

55.2

54.1

64.1

63.2

39.9

40.4

Surgical/Trauma

44.8

45.9

35.9

36.8

60.1

59.6

Mechanical ventilation (%)

45.8

35.4

N/A

N/A

84.2

82.0

ICU LOS

2.5 (1.1 to 5.7)

1.5 (0.9 to 3.1)

3.0 (1.8 to 6.9)

3.0 (1.7 to 6.3)

6.0 (3.0 to 13.0)

6.0 (3.0 to 12.5)

APACHE II score

16 (11 to 22)

14 (10 to 21)

19.7 (8.2)

19.4 (8.3)

15 (11 to 21)

15 (11 to 21)

Mortality (%)

19.2

14.2

27.5

26.0

17.8

22.9

Glucose control parameters

      

Number of BG measurements per patient

18 (9 to 47)

15 (8 to 34)

17 (7 to 38)

29 (12 to 69)

29 (12 to 74)

37 (15 to 93)

Number of BG measurements per day*

8.7 (5.7 to 10.5)

9.3 (8.0 to 11.3)

5.1 (3.6 to 7.6)

9.8 (6.8 to 12.1)

4.5 (3.2 to 6.7)

5.6 (3.8 to 9.0)

Mean (mg/dL)

124.4 (112.2 to 140.7)

124.0 (112.0 to 138.0)

127.7 (116.4 to 145.0)

117.9 (107.0 to 137.0)

146.3 (128.1 to 164.6)

118.5 (109.3 to 130.3)

CV (%)

23.8 (16.7 to 32.6)

21.0 (14.8 to 28.5)

26.9 (18.8 to 35.2)

31.8 (23.8 to 40.8)

20.7 (15.4 to 26.2)

26.2 (20.3 to 33.1)

SD (mg/dL)

29.5 (20.0 to 42.6)

25.9 (17.7 to 37.5)

33.8 (23.6 to 49.4)

37.1 (27.3 to 50.3)

29.3 (19.9 to 41.7)

30.5 (22.7 to 42.1)

Percentage of patients with hypoglycemia

      

< 40 mg/dL

6.7

2.9

8.8

18.1

2.4

9.5

40 to 54 mg/dL

12.6

8.4

13.6

25.2

3.9

23.1

55 to 69 mg/dL

17.7

14.9

19.3

21.6

11.5

31.3

< 70 mg/dL

37.0

26.2

41.7

64.9

17.8

63.9

  1. APACHE II, Acute Physiology and Chronic Health Evaluation II disease classification system; BG, blood glucose; CV, coefficient of variation; DM, diabetes mellitus; GL-C, patients in the control arm of the GLUCONTROL trial; GL-IIT, patients in the intervention arm of the GLUCONTROL trial; LOS, length of stay (days); NL-L, Netherlands "loose" cohort; NL-S, Netherlands "strict" cohort; SD, standard deviation; ST, Stamford cohort.
  2. *Calculated as (mean number of BG tests/mean ICU LOS). Data expressed as median (interquartile range), or percentages