Table 2 Infection characteristics of 76 patients with severe sepsis and septic shock according to whether ongoing statin therapy was maintained or not at ICU admission
Discontinuation group (n = 32) | Continuation group (n = 44) | P value | Absolute standardized difference* (%) | |
|---|---|---|---|---|
Infection site, n (%) | 0.74 | 13.5 | ||
Lung | 14 (44%) | 17 (39%) | ||
Urinary tract | 5 (16%) | 7 (16%) | ||
Bloodstream (primary) | 4 (13%) | 7 (16%) | ||
Others | 6 (19%) | 5 (11%) | ||
Unknown | 3 (9%) | 8 (18%) | ||
Causative organism, n (%) | 0.19 | 50.5 | ||
Gram-positive cocci | ||||
Staphylococcus sp. | 2 (6%) | 3 (7%) | ||
Streptococcus and Enterococcus sp. | 4 (13%) | 7 (16%) | ||
Gram-negative bacilli | ||||
Enterobacteriaceae sp | 7 (22%) | 13 (30%) | ||
Other Gram-negative bacilli | 4 (13%) | 6 (14%) | ||
Other organisms | 0 (0%) | 2 (5%) | ||
Polymicrobial | 12 (38%) | 5 (11%) | ||
Negative culture | 3 (9%) | 8 (18%) | ||
Type of infection, n (%) | <0.01 | 65.5 | ||
Community acquired | 11 (34%) | 29 (66%) | ||
Hospital acquired | 21 (66%) | 15 (34%) | ||
Adequation of initial antibiotic therapy, n (%) | 25 (78%) | 34 (77%) | 0.93 | 2.0 |
Low-dose corticosteroids, n (%) | 19 (59%) | 18 (41%) | 0.11 | 37.1 |
Activated protein C, n (%) | 2 (6%) | 0 (0%) | 0.09 | 35.9 |