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Figure 4 | Critical Care

Figure 4

From: Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: a retrospective cohort study

Figure 4

Atorvastatin plasma concentrations before and 90 minutes after receiving a 40 mg dose in nine critically ill septic patients continuing this drug while under cytochrome P450 3A4 inhibitors (in red) or not (in black). Two patients were assessed twice (circles). The residual concentrations reported in healthy volunteers after a single 20 mg dose are close to 3 ng/mL [26].

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