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Table 3 Renal biomarkers levels in fenoldopam group (F) and placebo group (P) before surgery (t0), at the end of surgical procedure (t1), and 12 hours after intensive care unit admission (t2)

From: High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery

 

T0

T1

T2

P

 

Group F

Group P

Group F

Group P

Group F

Group P

 

uNGAL (ng/ml)

37.2 (84.5)

37 (232)

94.2 (240)a

140 (249)

20.4 (15.7)a

57 (105)

0.025

pNGAL (ng/ml)

62 (33)

66 (31)

88 (38)

96 (40)

93 (45)

99 (41)

0.253

uCys C (mg/l)

0.12 (0.2)

0.08 (0.06)

0.16 (0.3)a

0.22 (0.5)

0.06 (0.04)

0.09 (0.13)

0.039

pCys C (mg/l)

1.0 (0.3)

1.1 (0.3)

0.96 (0.28)

1.0 (0.25)

1.19 (0.3)

1.3 (0.3)

0.344

pCrea (mg/dl)

0.51 (0.15)

0.46 (0.16)

0.63 (0.17)

0.64 (0.13)

0.64 (0.2)

0.62 (0.2)

0.114

uCrea (mg/dl)

53.5 (37.4)

49.6 (33.7)

8.5 (5.5)

8.5 (7.6)

26.4 (23.4)

26.4 (23.7)

0.707

  1. Mean (standard deviation) levels of plasma and urinary levels of creatinine (respectively, pCrea and uCrea), neutrophil gelatinase-associated lipocalin (respectively, pNGAL and uNGAL), and cystatine-C (respectively, pCysC and uCysC) are reported. aSignificant differences by Bonferroni post test of ANOVA. We found a significant difference between groups of uNGAL levels at t1 (P = 0.02) and t2 (P = 0.04) and of uCysC levels at t1 (P = 0.04). Data are expressed as mean (standard deviation).