Haemodynamic goal-directed therapy and postoperative infections: earlier is better. a systematic review and meta-analysis

Table 2 Subgroup analysis for postoperative infective complications^a

Analysis	Number of studies	References	Treatment group (episodes/total patients)	Control group (episodes/total patients)	OR (95% CI)	Pvalue	I ²
SSI high-risk patients	13	[22], [24, 25], [27], [30–32], [34], [36–38], [44], [46]	109/1,483	177/1,522	0.48 (0.33 to 0.70)	0.0001	21%
SSI studies providing definitions consistent with CDC criteria	8	[22], [25], [30–32], [36], [44, 45]	32/362	74/390	0.37 (0.23 to 0.58)	0.0001	0%
Pneumonia high-risk patients	12	[22], [24, 25], [30–32], [36, 37], [39], [42], [44], [46]	115/1,444	155/1,428	0.70 (0.54 to 0.91)	0.008	0%
Pneumonia studies providing definitions consistent with CDC criteria	9	[22], [25], [28], [30–32], [36, 37], [44]	99/1,289	141/1,341	0.70 (0.53 to 0.93)	0.01	0%
UTI high-risk patients	10	[22], [25], [30–32], [36], [38], [42], [44], [46]	13/458	31/449	0.44 (0.22 to 0.88)	0.02	1%
UTI studies providing definitions consistent with CDC criteria	7	[22], [25], [30–32], [36], [44]	9/298	24/326	0.45 (0.20 to 0.99)	0.05	0%

^a95% CI: 95% confidence interval; CDC: Centers for Disease Control and Prevention; I²: inconsistency; OR: odds ratio; SSI: surgical site infection; UTI: urinary tract infection.

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