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Figure 7 | Critical Care

Figure 7

From: Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice

Figure 7

Renal failure induced by ischemia-reperfusion prevented by dexmedetomidine (Dex). Mice received Dex before or after IRI and kidney injury was induced by clamping the right renal pedicle for 40 minutes while the contralateral kidney was removed. The animals were allowed for 24 hrs before functional measurements (A - Creatinine; B - Urea), or up to seven days for the long term Kaplan-Meier survival curve analysis (n = 10) (C). Atip = atipamazole; IRI = Ischemia reperfusion injury. Data are mean ± SD (n = 5). **P < 0.01 vs control. +P < 0.05, ++P < 0.01 vs IRI.

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