Figure 6
From: Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
Anti-inflammatory effect afforded by dexmedetomidine (Dex) in vivo. Toll-like receptor 4 (TLR4) expression was assessed with in situ immunostaining and Western blot. Naïve control (A); Renal ischemia-reperfusion injury (IRI) (B); Dex+IRI (C); Atip (atipamazole) + pre-Dex+IRI (D) and Western blot (E). (F) Plasma level of High-mobility group protein B1 (HMGB1). Bar = 100 μm. Data are mean ± SD (n = 4). **P < 0.01 vs control. +P < 0.05, ++P < 0.01 vs IRI.