Figure 5
From: Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
In vivo renoprotection afforded by dexmedetomidine (Dex) vs renal ischemia-reperfusion injury (IRI). Adult male Mice were pretreated or post-treated with Dex alone or in combination with α2 adrenoceptor antagonist, atipamazole (Atip) (1 nM) and the renoprotection of Dex was assessed with plasma creatinine (A) and urea measurement (B). Data are mean ± SD (n = 5 to 6). * P < 0.05, **P < 0.01 vs control. +P < 0.05, ++P < 0.01 vs IRI.