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Table 4 Effects of different factors on outcome for sepsis subgroup (n = 327) by using univariate logistic regression analyses

From: Gender-related outcome difference is related to course of sepsis on mixed ICUs: a prospective, observational clinical study

  Univariate logistic analysis Multivariate logistic analysis
Parameter OR (95% CI) P OR (95% CI) P
Gender ♀ vs. ♂ 1.889 (1.062-3.359) 0.030 1.909 (1.002-3.638) 0.049
Age 1.036 (1.014-1.059) 0.001 1.037 (1.013-1.063) 0.003
Alcohol abuse 0.972 (0.408-2.317) 0.948   
Nicotine abuse 0.428 (0.126-1.453) 0.174   
Drug abuse 0.719 (0.158-3.277) 0.670   
Immune suppression 0.740 (0.247-2.214) 0.590   
TISS-28 first 1.063 (1.033-1.093) < 0.001 1.062 (1.028-1.098) < 0.001
Infection type     
   Pneumonia 1.960 (1.048-3.664) 0.035 1.120 (0.539-2.324) 0.762
   Urinary tract infection 0.790 (0.316-1.977) 0.614   
   Abdomen 1.047 (0.477-2.298) 0.908   
   Bones and joints 0.782 (0.170-3.593) 0.752   
   Endocarditis 0.665 (0.147-3.010) 0.596   
   Meningitis 0.786 (0.093-6.655) 0.825   
   Wounds/Soft issue 0.787 (0.408-1.519) 0.476   
   BSI 1.589 (0.162-15.560) 0.691   
   Colitis, pseudomembranous 1.589 (0.162-15.560) 0.691   
   Infection of unknown origin 0.667 (0.249-1.788) 0.421   
Severe sepsisa 1.845 (1.037-3.280) 0.037   
Septic shock 2.418 (1.354-4.319) 0.003 1.649 (0.854-3.184) 0.136
ICU diagnoses     
   Infection 1.492 (0.468-4.755) 0.499   
   Neoplastic 0.939 (0.414-2.130) 0.880   
   Neurologic 0.319 (0.095-1.071) 0.065   
   Cardiovascular 1.146 (0.624-2.107) 0.660   
   Respiratory 2.523 (1.117-5.699) 0.026 1.374 (0.521-3.620) 0.520
   Gastrointestinal 1.263 (0.490-3.259) 0.629   
   Trauma 0.428 (0.126-1.453) 0.174   
   Miscellaneous 0.943 (0.310-2.873) 0.918   
   Postoperative admission 1.165 (0.581-2.336) 0.667   
Type of surgery     
   Head 1.079 (0.450-2.589) 0.864   
   Musculoskeletal 0.573 (0.232-1.414) 0.227   
   Cardiac 1.335 (0.691-2.577) 0.390   
   Abdomen/Urogenital 0.954 (0.474-1.919) 0.894   
   Thorax 1.055 (0.222-5.016) 0.947   
   Soft tissues and peripheral vascular 3.694 (0.804-16.981) 0.093   
Fungi detected 2.297 (1.282-4.118) 0.005 1.523 (0.782-2.968) 0.216
Gram-negative bacteria detected 1.341 (0.756-2.379) 0.315   
Difficult-to-treat pathogens detectedb 1.300 (0.652-2.594) 0.457   
SOP adherence ≤65% 1.139 (0.632-2.052) 0.664   
  1. Parameters found to be relevant on a P < 0.05 level for ICU mortality entered multivariate logistic regression analysis. Quality of regression model tested with Hosmer-Lemeshow test indicating good calibration (χ2 = 7.014; P = 0.535). BSI, blood stream infection; SOP, standard operating procedure.
  2. aSeptic shock entered multivariate analysis due to correlation; bDifficult-to-treat pathogens include bacteria associated with potential intrinsic or acquired resistance (methicillin-resistant Staphylococcus aureus, germs producing extended spectrum betalactamases, vancomycin-resistant Enterococci, Nonfermenters like Pseudomonas spp., Stenotrophomonas maltophilia, Acinetobacter baumanii, Citrobacter spp., Enterobacter cloacae, Enterococcus faecium, and Bacillus cereus).