| |
Univariate logistic analysis
|
Multivariate logistic analysis
|
|---|
|
Parameter
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
|---|
|
Gender ♀ vs. ♂
|
1.889 (1.062-3.359)
|
0.030
|
1.909 (1.002-3.638)
|
0.049
|
|
Age
|
1.036 (1.014-1.059)
|
0.001
|
1.037 (1.013-1.063)
|
0.003
|
|
Alcohol abuse
|
0.972 (0.408-2.317)
|
0.948
| | |
|
Nicotine abuse
|
0.428 (0.126-1.453)
|
0.174
| | |
|
Drug abuse
|
0.719 (0.158-3.277)
|
0.670
| | |
|
Immune suppression
|
0.740 (0.247-2.214)
|
0.590
| | |
|
TISS-28 first
|
1.063 (1.033-1.093)
|
< 0.001
|
1.062 (1.028-1.098)
|
< 0.001
|
|
Infection type
| | | | |
|
Pneumonia
|
1.960 (1.048-3.664)
|
0.035
|
1.120 (0.539-2.324)
|
0.762
|
|
Urinary tract infection
|
0.790 (0.316-1.977)
|
0.614
| | |
|
Abdomen
|
1.047 (0.477-2.298)
|
0.908
| | |
|
Bones and joints
|
0.782 (0.170-3.593)
|
0.752
| | |
|
Endocarditis
|
0.665 (0.147-3.010)
|
0.596
| | |
|
Meningitis
|
0.786 (0.093-6.655)
|
0.825
| | |
|
Wounds/Soft issue
|
0.787 (0.408-1.519)
|
0.476
| | |
|
BSI
|
1.589 (0.162-15.560)
|
0.691
| | |
|
Colitis, pseudomembranous
|
1.589 (0.162-15.560)
|
0.691
| | |
|
Infection of unknown origin
|
0.667 (0.249-1.788)
|
0.421
| | |
|
Severe sepsisa
|
1.845 (1.037-3.280)
|
0.037
| | |
|
Septic shock
|
2.418 (1.354-4.319)
|
0.003
|
1.649 (0.854-3.184)
|
0.136
|
|
ICU diagnoses
| | | | |
|
Infection
|
1.492 (0.468-4.755)
|
0.499
| | |
|
Neoplastic
|
0.939 (0.414-2.130)
|
0.880
| | |
|
Neurologic
|
0.319 (0.095-1.071)
|
0.065
| | |
|
Cardiovascular
|
1.146 (0.624-2.107)
|
0.660
| | |
|
Respiratory
|
2.523 (1.117-5.699)
|
0.026
|
1.374 (0.521-3.620)
|
0.520
|
|
Gastrointestinal
|
1.263 (0.490-3.259)
|
0.629
| | |
|
Trauma
|
0.428 (0.126-1.453)
|
0.174
| | |
|
Miscellaneous
|
0.943 (0.310-2.873)
|
0.918
| | |
|
Postoperative admission
|
1.165 (0.581-2.336)
|
0.667
| | |
|
Type of surgery
| | | | |
|
Head
|
1.079 (0.450-2.589)
|
0.864
| | |
|
Musculoskeletal
|
0.573 (0.232-1.414)
|
0.227
| | |
|
Cardiac
|
1.335 (0.691-2.577)
|
0.390
| | |
|
Abdomen/Urogenital
|
0.954 (0.474-1.919)
|
0.894
| | |
|
Thorax
|
1.055 (0.222-5.016)
|
0.947
| | |
|
Soft tissues and peripheral vascular
|
3.694 (0.804-16.981)
|
0.093
| | |
|
Fungi detected
|
2.297 (1.282-4.118)
|
0.005
|
1.523 (0.782-2.968)
|
0.216
|
|
Gram-negative bacteria detected
|
1.341 (0.756-2.379)
|
0.315
| | |
|
Difficult-to-treat pathogens detectedb
|
1.300 (0.652-2.594)
|
0.457
| | |
|
SOP adherence ≤65%
|
1.139 (0.632-2.052)
|
0.664
| | |
- Parameters found to be relevant on a P < 0.05 level for ICU mortality entered multivariate logistic regression analysis. Quality of regression model tested with Hosmer-Lemeshow test indicating good calibration (χ2 = 7.014; P = 0.535). BSI, blood stream infection; SOP, standard operating procedure.
- aSeptic shock entered multivariate analysis due to correlation; bDifficult-to-treat pathogens include bacteria associated with potential intrinsic or acquired resistance (methicillin-resistant Staphylococcus aureus, germs producing extended spectrum betalactamases, vancomycin-resistant Enterococci, Nonfermenters like Pseudomonas spp., Stenotrophomonas maltophilia, Acinetobacter baumanii, Citrobacter spp., Enterobacter cloacae, Enterococcus faecium, and Bacillus cereus).
