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Table 3 Effects of different factors on outcome in a mixed ICU population for study population

From: Gender-related outcome difference is related to course of sepsis on mixed ICUs: a prospective, observational clinical study

 

Univariate logistic analysis

Multivariate logistic analysis

Parameter

OR (95% CI)

P

OR (95% CI)

P

Gender ♀ vs. ♂

1.209 (0.735-1.988)

0.455

1.277 (0.720-2.264)

0.403

Age

1.035 (1.015-1.055)

< 0.001

1.041 (1.018-1.064)

< 0.001

Alcohol abuse

1.341 (0.611-2.943)

0.464

  

Nicotine abuse

0.526 (0.186-1.490)

0.227

  

Drug abuse

0.976 (0.222-4.280)

0.974

  

Immune suppression

0.668 (0.234-1.904)

0.450

  

TISS-28 first

1.080 (1.053-1.108)

< 0.001

1.066 (1.035-1.097)

< 0.001

Infection during ICU stay

3.881 (1.745-8.633)

0.001

1.269 (0.487-3.304)

0.626

Infection type

    

   Pneumonia

4.370 (2.613-7.311)

< 0.001

1.377 (0.676-2.802)

0.378

   Urinary tract infection

1.694 (0.728-3.941)

0.221

  

   Abdomen

1.477 (0.698-3.127)

0.308

  

   Bones and joints

1.164 (0.262-5.173)

0.842

  

   Endocarditis

1.164 (0.262-5.173)

0.842

  

   Meningitis

1.031 (0.129-8.262)

0.977

  

   Wounds/soft issue

1.310 (0.713-2.404)

0.384

  

   BSI

2.338 (0.258-21.220)

0.450

  

   Colitis, pseudomembranous

2.338 (0.258-21.220)

0.450

  

   Infection of unknown origin

0.883 (0.341-2.292)

0.799

  

Severe sepsisa

4.110 (2.448-6.900)

< 0.001

  

Septic shock

5.023 (2.963-8.515)

< 0.001

2.746 (1.328-5.680)

0.006

ICU diagnoses

    

   Infection

2.553 (0.922-7.068)

0.071

  

   Neoplastic

0.556 (0.269-1.149)

0.113

  

   Neurologic

0.348 (0.107-1.134)

0.08

  

   Cardiovascular

1.170 (0.700-1.956)

0.548

  

   Respiratory

4.306 (2.032-9.125)

< 0.001

1.447 (0.542-3.860)

0.461

   Gastrointestinal

1.322 (0.542-3.229)

0.540

  

   Trauma

0.526 (0.186-1.490)

0.227

  

   Miscellaneous

0.815 (0.315-2.108)

0.673

  

Postoperative admission

0.865 (0.457-1.637)

0.655

  

Type of surgery

    

   Head

0.905 (0.399-2.053)

0.811

  

   Musculoskeletal

0.972 (0.481-1.967)

0.938

  

   Cardiac

1.136 (0.661-1.951)

0.645

  

   Abdomen/urogenital

0.658 (0.351-1.233)

0.191

  

   Thorax

1.164 (0.262-5.173)

0.842

  

   Soft tissues and peripheral vascular

4.803 (1.174-19.651)

0.029

3.509 (0.613-20.073)

0.158

Fungi detected

4.255 (2.492-7.266)

< 0.001

1.398 (0.701-2.788)

0.341

Gram-negative bacteria detected

2.929 (1.748-4.906)

< 0.001

1.234 (0.605-2.513)

0.563

Difficult-to-treat pathogens detectedb

2.421 (1.248-4.697)

0.009

1.115 (0.499-2.493)

0.791

SOP adherence ≤65%

1.705 (1.011-2.874)

0.045

2.309 (1.182-4.511)

0.014

  1. Effects of different factors on outcome in a mixed ICU population for study population (N = 709) by using univariate logistic regression analyses. Parameters found to be relevant on a P < 0.05 level for ICU mortality entered multivariate logistic regression analysis. Quality of regression model tested with the Hosmer-Lemeshow test, indicating good calibration (χ2 = 4.672; P = 0.792). BSI, bloodstream infection; SOP, standard operating procedure; TISS-28, therapeutic intervention scoring system-28.
  2. aSeptic shock entered multivariate analysis due to correlation; bDifficult-to-treat pathogens include bacteria associated with potential intrinsic or acquired resistance (methicillin-resistant Staphylococcus aureus, germs producing extended spectrum betalactamases, vancomycin-resistant Enterococci, nonfermenters like Pseudomonas spp., Stenotrophomonas maltophilia, Acinetobacter baumanii, Citrobacter spp., Enterobacter cloacae, Enterococcus faecium, and Bacillus cereus).
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Critical Care

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