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Table 3 Effects of different factors on outcome in a mixed ICU population for study population

From: Gender-related outcome difference is related to course of sepsis on mixed ICUs: a prospective, observational clinical study

  Univariate logistic analysis Multivariate logistic analysis
Parameter OR (95% CI) P OR (95% CI) P
Gender ♀ vs. ♂ 1.209 (0.735-1.988) 0.455 1.277 (0.720-2.264) 0.403
Age 1.035 (1.015-1.055) < 0.001 1.041 (1.018-1.064) < 0.001
Alcohol abuse 1.341 (0.611-2.943) 0.464   
Nicotine abuse 0.526 (0.186-1.490) 0.227   
Drug abuse 0.976 (0.222-4.280) 0.974   
Immune suppression 0.668 (0.234-1.904) 0.450   
TISS-28 first 1.080 (1.053-1.108) < 0.001 1.066 (1.035-1.097) < 0.001
Infection during ICU stay 3.881 (1.745-8.633) 0.001 1.269 (0.487-3.304) 0.626
Infection type     
   Pneumonia 4.370 (2.613-7.311) < 0.001 1.377 (0.676-2.802) 0.378
   Urinary tract infection 1.694 (0.728-3.941) 0.221   
   Abdomen 1.477 (0.698-3.127) 0.308   
   Bones and joints 1.164 (0.262-5.173) 0.842   
   Endocarditis 1.164 (0.262-5.173) 0.842   
   Meningitis 1.031 (0.129-8.262) 0.977   
   Wounds/soft issue 1.310 (0.713-2.404) 0.384   
   BSI 2.338 (0.258-21.220) 0.450   
   Colitis, pseudomembranous 2.338 (0.258-21.220) 0.450   
   Infection of unknown origin 0.883 (0.341-2.292) 0.799   
Severe sepsisa 4.110 (2.448-6.900) < 0.001   
Septic shock 5.023 (2.963-8.515) < 0.001 2.746 (1.328-5.680) 0.006
ICU diagnoses     
   Infection 2.553 (0.922-7.068) 0.071   
   Neoplastic 0.556 (0.269-1.149) 0.113   
   Neurologic 0.348 (0.107-1.134) 0.08   
   Cardiovascular 1.170 (0.700-1.956) 0.548   
   Respiratory 4.306 (2.032-9.125) < 0.001 1.447 (0.542-3.860) 0.461
   Gastrointestinal 1.322 (0.542-3.229) 0.540   
   Trauma 0.526 (0.186-1.490) 0.227   
   Miscellaneous 0.815 (0.315-2.108) 0.673   
Postoperative admission 0.865 (0.457-1.637) 0.655   
Type of surgery     
   Head 0.905 (0.399-2.053) 0.811   
   Musculoskeletal 0.972 (0.481-1.967) 0.938   
   Cardiac 1.136 (0.661-1.951) 0.645   
   Abdomen/urogenital 0.658 (0.351-1.233) 0.191   
   Thorax 1.164 (0.262-5.173) 0.842   
   Soft tissues and peripheral vascular 4.803 (1.174-19.651) 0.029 3.509 (0.613-20.073) 0.158
Fungi detected 4.255 (2.492-7.266) < 0.001 1.398 (0.701-2.788) 0.341
Gram-negative bacteria detected 2.929 (1.748-4.906) < 0.001 1.234 (0.605-2.513) 0.563
Difficult-to-treat pathogens detectedb 2.421 (1.248-4.697) 0.009 1.115 (0.499-2.493) 0.791
SOP adherence ≤65% 1.705 (1.011-2.874) 0.045 2.309 (1.182-4.511) 0.014
  1. Effects of different factors on outcome in a mixed ICU population for study population (N = 709) by using univariate logistic regression analyses. Parameters found to be relevant on a P < 0.05 level for ICU mortality entered multivariate logistic regression analysis. Quality of regression model tested with the Hosmer-Lemeshow test, indicating good calibration (χ2 = 4.672; P = 0.792). BSI, bloodstream infection; SOP, standard operating procedure; TISS-28, therapeutic intervention scoring system-28.
  2. aSeptic shock entered multivariate analysis due to correlation; bDifficult-to-treat pathogens include bacteria associated with potential intrinsic or acquired resistance (methicillin-resistant Staphylococcus aureus, germs producing extended spectrum betalactamases, vancomycin-resistant Enterococci, nonfermenters like Pseudomonas spp., Stenotrophomonas maltophilia, Acinetobacter baumanii, Citrobacter spp., Enterobacter cloacae, Enterococcus faecium, and Bacillus cereus).
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