High-sensitivity versus conventional troponin in the emergency department for the diagnosis of acute myocardial infarction

Table 2 Baseline characteristics of the population according to the pretest probability^a

Population characteristics	All patients	Low or moderate PTP	High PTP	Pvalue*
Number of patients	317	258	59
Age, years	57 ± 17	56 ± 17	60 ± 17	0.168
Men	205 (65)	166 (64)	39 (66)	0.88
Systolic BP, mmHg	141 ± 28	141 ± 27	144 ± 30	0.396
Diastolic BP, mmHg	80 ± 16	80 ± 16	82 ± 16	0.428
Heart rate, beats/minute	85 ± 45	84 ± 23	80 ± 19	0.177
Pulse oxymetry, %	97 ± 3	97 ± 3	97 ± 2	0.651
TIMI risk score	1 (0 to 3)	1 (0 to 2)	2 (1 to 4)	< 0.001
Family history of CAD	100 (32)	77 (30)	23 (59)	0.161
Personal history of CAD	83 (26)	56 (22)	27 (46)	0.0003
Dyslipidemia	113 (36)	86 (33)	27 (46)	0.069
Smoking	128 (40)	99 (38)	29 (49)	0.145
Diabetes	44 (14)	31 (12)	13 (22)	0.059
Hypertension	116 (37)	89 (34)	27 (46)	0.134
History of heart failure	21 (7)	14 (5)	7 (12)	0.083
Typical thoracic pain	136 (43)	105 (41)	31 (53)	0.11
Positive cTnI at admission	41 (13)	24 (9)	17 (29)	< 0.001**
eGFR, mL/minute/1.73 m²	77 (62 to 94)	77 (64 to 94)	76 (56 to 91)	0.187
Treatment within first 24 hours after admission
Aspirin	119 (38)	79 (31)	40 (68)	<0.001
Clopidogrel	54 (17)	29 (11)	25 (42)	< 0.001
LMWH	68 (21)	41 (16)	27 (46)	< 0.001
Anti GPIIb/IIIa	3 (1)	1 (0)	2 (3)	0.09
Coronarography	83 (26)	51 (20)	32 (54)	< 0.001
Outcomes
Hospital admission	192 (61)	140 (54)	52 (88)	< 0.001
Admission to CCU	134 (42)	88 (34)	46 (78)	< 0.001
Final diagnosis
AMI	45 (14)	22 (9)	23 (39)	< 0.001
STEMI	13 (4)	0 (0)	13 (22)	< 0.001
NSTEMI	32 (10)	22 (9)	10 (17)	< 0.001
Unstable angina	11 (3)	4 (2)	7 (12)	< 0.001
Other diagnosis	261 (82)	232 (90)	29 (49)	< 0.001***

^aAMI, acute myocardial infarction; BP, blood pressure; CAD, coronary artery disease; cTnI, conventional troponin I; eGFR, estimated glomerular filtration rate; LMWH, low-molecular-weight heparin; anti-GPIIb/IIIa, Anti-glycoprotein IIb-IIIa; CCU, cardiologic care unit; NSTEMI, non-ST elevation myocardial infarction; PTP, pretest probability; STEMI, ST elevated myocardial infarction. TIMI, Thrombolysis in Myocardial Infarction. Results are expressed as means ± standard deviations, medians (25th to 75th percentile) or n (%); *statistical comparisons are between low to moderate PTP and high PTP groups unless otherwise indicated; **P > 0.14 μg/L in Pitie-Salpetriere and Cochin, P > 0.06 μg/L in Bicêtre; ***Statistical comparison including stable angina (n = 63), pulmonary embolism (n = 16), myopericarditis (n = 43), heart failure (n = 5) and others.

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