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Table 2Table 2 Criteria used to define individual organ dysfunctiona

From: Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT Study

Type of dysfunction

Definition

Cardiovascular

Systolic arterial pressure ≤ 90 mmHg after adequate fluid resuscitation

Respiratory

PaO2/FiO2 ratio ≤ 300 and, if measured, pulmonary capillary wedge pressure not suggestive of central volume overload

Hematologic

Platelet count ≤ 100,000/mm3 or 50% drop in the past 72 hours or relevant changes in coagulation profile (INR > 1.5 or aPTT > 60 seconds)

Renal

Urine output < 0.5 mL/kg/hour for at least 2 hours, even after fluid resuscitation or creatinine > 2.0 mg/dL

Metabolic

pH < 7.30 or base excess less than -5 mEq/L with plasma lactate > 1.5 × normal value

Hepatic

Total bilirubin > 2.0 mg/dL or 35 mmol/L

  1. aPaO2/FiO2 ratio = ratio of partial pressure of oxygen to fraction of inspired oxygen; INR = International Normalized Ratio; aPTT = activated partial thromboplastin time.