Type of dysfunction | Definition |
---|---|
Cardiovascular | Systolic arterial pressure ≤ 90 mmHg after adequate fluid resuscitation |
Respiratory | PaO2/FiO2 ratio ≤ 300 and, if measured, pulmonary capillary wedge pressure not suggestive of central volume overload |
Hematologic | Platelet count ≤ 100,000/mm3 or 50% drop in the past 72 hours or relevant changes in coagulation profile (INR > 1.5 or aPTT > 60 seconds) |
Renal | Urine output < 0.5 mL/kg/hour for at least 2 hours, even after fluid resuscitation or creatinine > 2.0 mg/dL |
Metabolic | pH < 7.30 or base excess less than -5 mEq/L with plasma lactate > 1.5 × normal value |
Hepatic | Total bilirubin > 2.0 mg/dL or 35 mmol/L |