Table 2 Pharmacokinetic parameters of the four antibiotics
Antibiotic (number of series) | Vd (l/kg) | Cmax (μg/ml) | Cmin (μg/ml) | AUC (mg/hour/ml) | CL (ml/minute/kg) | t1/2 (hours) |
|---|---|---|---|---|---|---|
MEM 1 g twice daily (n = 22) | 0.45 (0.20 to 3.03) | 26 (15 to 67) | 6 (2 to 11) | 134 (61 to 291) | 1.15 (0.54 to 3.37) | 4.39 (2.61 to 30.5) |
TZP 4.0/0.5 g four times daily (n = 21) | 0.44 (0.22 to 1.72) | 138 (36 to 262) | 60 (4 to 155) | 527 (62 to 1378) | 1.15 (0.27 to 6.26) | 4.16 (1.05 to 15.3) |
FEP 2 g twice daily (n = 11) | 0.55 (0.33 to 0.94) | 43 (28 to 83) | 11 (3 to 22) | 379 (148 to 483) | 1.04 (0.43 to 2.97) | 6.17 (3.30 to 22.9) |
CAZ 2 g twice daily (n = 15) | 0.37 (0.22 to 0.84) | 78 (54 to 118) | 24 (5 to 46) | 536 (258 to 906) | 0.52 (0.13 to 1.61) | 7.74 (2.52 to 33.5) |