A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome

Table 2 Respiratory variables during the first 24 hrs of treatment (mean ± SE)

	1 hour		3 hours		6 hours		24 hours
	PHARLAP	Control	PHARLAP	Control	PHARLAP	Control	PHARLAP	Control
V_T, mls	519 ± 56	501 ± 30	517 ± 51	529 ± 58	529 ± 56	542 ± 49	463 ± 42	563 ± 65
RR, bpm	21 ± 2	21 ± 1	20 ± 2	21 ± 2	21 ± 2	21 ± 2	22 ± 2	20 ± 2
F_IO₂	0.47 ± 0.03	0.59 ± 0.04	0.5 ± 0.04	0.5 ± 0.03	0.4 ± 0.05	0.57 ± 0.05	0.4 ± 0.04	0.5 ± 0.04
PEEP, cm H₂O	17.4 ± 1	11.6 ± 1	17.4 ± 1*	11 ± 0.5	16.7 ± 1*	10 ± 0.6	15 ± 1*	10 ± 0.5
Pplateau, cm H₂O	28.9 ± 1.2	27.1 ± 1.2	28.3 ± 1.1	26.6 ± 1.1	29 ± 0.8	26 ± 0.8	27.6 ± 1.5	26.9 ± 1.4
Arterial pH	7.34 ± 0.02	7.36 ± 0.02	7.34 ± 0.02	7.34 ± 0.03	7.34 ± 0.02	7.36 ± 0.01	7.36 ± 0.01	7.35 ± 0.01
PaCO₂, mm Hg	49 ± 5	46 ± 5	47 ± 4	48 ± 6	48 ± 3	45 ± 3	45 ± 3	46 ± 3

*P < 0.05 for differences between PHARLAP and control groups.
V_T, tidal volume; RR, respiratory rate; F_IO₂, fraction of inspired oxygen; PEEP, positive end expiratory pressure; Pplateau, plateau pressure; PaO₂/F_IO₂, partial pressure of oxygen to inspired fraction of oxygen ratio; PaCO₂, partial pressure of carbon dioxide

ISSN: 1364-8535