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Table 1 RIFLE classificationa

From: Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis

RIFLE class GFR criteria UO criteria
Risk Increase in serum creatinine ≥1.5 × baseline or decrease in GFR ≥25% <0.5 ml/kg/hour for ≥6 hours
Injury Increase in serum creatinine ≥2 × baseline or decrease in GFR ≥ 50% <0.5 ml/kg/hour for ≥12 hours
Failure Increase in serum creatinine ≥3 × baseline or decrease in GFR ≥75% or serum creatinine ≥350 μmol/L with an acute rise of at least 44 μmol/L <0.3 ml/kg/hour for ≥24 hours or anuria ≥12 hours
Loss Complete loss of kidney function >4 weeks
End-stage kidney disease Need for RRT >3 months
  1. aGFR, glomerular filtration rate; UO, urine output; RRT, renal replacement therapy.