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Table 3 Analysis of the treatment effect according to different dichotomizations and proportional odds logistic regression

From: The added value of ordinal analysis in clinical trials: an example in traumatic brain injury

 

Adjusted odds ratio^ (95% CI)

Wald statistic

P-value

Dichotomous odds ratios

   

   Less than good vs. good recovery

1.12 (1.01 to 1.23)

2.26

0.024

   Unfavourable vs. favourable outcome

1.09 (0.98 to 1.21)

1.66

0.096

   Death vs. survival

1.27 (1.13 to 1.43)

4.16

< 0.0001

Common odds ratio (proportional odds model)

1.15 (1.06 to 1.25)

3.41

0.0007

  1. Analyses are based on the six-month Glasgow Outcome Scale. Data from the CRASH trial (n = 9,554).
  2. An odds ratio > 1 indicates an adverse effect of corticosteroids.
  3. ^ Adjustment for age, GCS, pupillary reactivity and major extracranial injury
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Critical Care

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