Figure 6

Serial changes from baseline in levels of FDP in the two groups. Data are expressed as group means ± standard error of the mean. The degree of decrease in FDP level was significantly greater in the rhTM group than in the control group (P = 0.017). The decrease of FDP level over time and the interaction between treatment and time were not significant (P = 0.844 and P = 0.525, respectively), probably because of small sample size and considerable variation. Because we included in our analysis only patients for whom baseline values and subsequent values were recorded, only 23 of 45 patients were included in the control group. The last-observation-carried-forward method of imputation was used for missing data. The imputation was accomplished in a total of one value in one patient for the rhTM group and in a total of 12 values in 12 patients for the control group. *P < 0.05 compared to the control group. FDP, fibrinogen degradation products; rhTM, recombinant human soluble thrombomodulin.