Table 1 Pharmacokinetics and PK-PD correlation for six anti-infective agents for a burn child [AQ2]
From: PK-PD correlation of anti-infective agents for dose adjustment in one severe burn child with sepsis
Drug efficacy (%)a/MIC(mg/l)b | t1/2 (hours) | CL (ml/minute/kg) | Vd (l/kg) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Drug | Follow-up periods | Obtained | Referencec | Obtained | Referencec | Obtained | Referencec | |||
Fluconazole | 1 | 100% | 100% | 100% | 22.10 | 27 to 37 | 0.27 | 0.20 to 0.34 | 0.53 | 0.50 to 0.70 |
8 mg/ml | 16 mg/ml | 32 mg/ml | ||||||||
Imipenem | 3 | 100% | 100% | 100% | 1.90 | 0.8 to 1.0 | 4.62 | 2.6 to 3.1 | 0.76 | 0.18 to 0.28 |
0.5 mg/ml | 1 mg/ml | 4 mg/ml | ||||||||
Linezolid | 2 | 100% | 50% | 0% | 3.45 | 4.5 to 5.4 | 3.22 | 1.14 to 2.08 | 0.95 | 0.57 to 0.86 |
1 mg/ml | 2 mg/ml | 4 mg/ml | ||||||||
Meropenem | 8 | 100% | 100% | 62% | 2.00 | 1.0 | 3.81 | 2.7 to 4.3 | 0.60 | 0.17 to 0.28 |
0.5 mg/ml | 2 mg/ml | 8 mg/ml | ||||||||
Sulphamethoxazole | 2 | 50% | 50% | ND | 19.65 | 7.5 to 12.7 | 0.74 | 0.24 to 0.38 | 1.34 | 0.22 to 0.30 |
32 mg/ml | 64 mg/ml | ND | ||||||||
Vancomycin | 5 | 80% | 60% | 60% | 2.10 | 5.0 to 11.0 | 1.46 | 1.3 to 1.5 | 0.30 | 0.33 to 0.45 |
1 mg/ml | 2 mg/ml | 4 mg/ml | ||||||||