Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation

Table 3 Univariate and multivariate analyses for predictors of 28-day mortality

	Univariate			Multivariate
Variables	HR	95% CI	P value	HR	95% CI	P value
Platelet (>112 vs. ≤112 × 10⁹/L)	5.54	1.64-18.75	0.012	1.30	0.18-9.50	0.797
Prothrombin time (≤18.4 vs. >18.4 s)	7.25	2.94-17.85	<0.001	2.20	0.17-29.07	0.548
D-dimer (≤2.0 vs. >2.0 μg/mL)	8.57	2.00-36.69	0.004	3.48	0.45-27.11	0.233
Fibrinogen (>118 vs. ≤118 mg/dL)	7.35	2.92-18.48	<0.001	22.35	2.25-221.81	0.008
Antithrombin (>35% vs. ≤35%)	7.50	3.18-17.65	<0.001	2.15	0.13-36.70	0.598
Protein C (>27% vs. ≤27%)	4.04	1.74-9.37	0.001	1.63	0.06-47.58	0.777
Soluble tissue factor (≤106.1 vs. >106.1 pg/mL)	3.59	2.71-18.47	<0.001	1.20	1.73-8.36	0.852
Absolute monocyte count (≤755 vs. >755 × 10⁶/L)	3.76	1.61-8.81	0.002	2.31	0.39-13.71	0.359
CD14^brightCD16^negative classical monocytes
Percentage (>57.9% vs. ≤57.9%)	8.16	2.41-27.61	0.001	4.94	0.66-37.01	0.120
Thrombomodulin (≤60.9 vs. >60.9)	4.93	2.06-11.81	<0.001	1.36	0.36-5.18	0.649
Tissue factor (>3.8 vs. ≤3.8)	2.14	0.90-5.11	0.086	5.27	1.14-24.47	0.034
CD14^brightCD16^positive inflammatory monocytes
Percentage (≤10.7% vs. >10.7%)	1.80	0.78-4.17	0.171	1.36	0.25-7.25	0.722
Thrombomodulin (≤63.2 vs. >63.2)	4.67	1.82-11.94	0.001	19.11	1.51-241.47	0.023
Tissue factor (≤4.3 vs. >4.3)	3.03	0.71-12.98	0.135	1.36	0.07-25.34	0.836
CD14^dimCD16^positive dendritic monocytes
Percentage (>4.1% vs. ≤4.1%)	2.17	0.93-5.08	0.074	5.14	0.81-32.40	0.082
Thrombomodulin (>83.4 vs. ≤83.4)	1.67	0.40-3.98	0.249	1.12	0.13-9.85	0.918
Tissue factor (>7.0 vs. ≤7.0)	2.21	0.93-5.24	0.073	1.28	0.26-6.22	0.762

The cutoff values were determined as the values at which the best prognostic value was produced.
The expression levels of thrombomodulin and tissue factor were scaled by an arbitrary unit of mean fluorescence intensity. CI, confidence interval; HR, hazard ratio.

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