Skip to main content

Table 1 Risk factors of ICU death

From: Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa

Variables Survivors (n = 136) Deaths (n = 87) P
Male sex 105 (77) 69 (79) 0.86
Age 66 (52 to 76) 70 (57 to 77) 0.04
Category at admission Medical 90 (66) 62 (71) 0.49
  Emergency surgery 25 (18) 17 (19) 0.76
  Scheduled surgery 21 (15) 8 (9) 0.20
Severity score at admission LOD 6 (4 to 8) 7 (5 to 10) 0.04
  SAPS II 45 (36 to 53) 54 (42 to 66) 0.0001
  SOFA 8 (6 to 10) 9 (6 to 11) 0.03
Duration of ICU stay before VAP 10 (6 to 18) 9 (5 to 18) 0.13
Duration of stay ICU 32 (20 to 50) 26(14 to 41) 0.19
  Hospital 57 (42 to 84) 30 (19 to 59) <0.0001
Main diagnosis at admission Septic shock 25 (18) 18 (21) 0.74
  Multiple organ failure 6 (4) 6 (7) 0.26
  Cardiac failure 5 (4) 2 (2) 0.53
  Acute respiratory failure 47 (35) 27 (31) 0.59
  COPD exacerbation 9 (7) 5 (6) 0.96
  Acute renal failure 3 (2) 2 (2) 0.90
  Scheduled surgery 9 (7) 1 (1) 0.08
Chronic illness Cardiovascular 16 (12) 19 (22) 0.03
  Pulmonary 31 (23) 22 (25) 0.58
  Renal 6 (4) 4 (5) 0.90
  Hepatic 6 (4) 7 (8) 0.29
  Diabetes 20 (15) 9 (10) 0.73
  At least one chronic illness 59 (43) 51 (59) 0.02
Treatment at admission Vasopressors 84 (62) 59 (68) 0.30
  Steroids 39 (29) 35 (40) 0.05
  Broad-spectrum antimicrobials 88 (65) 58 (67) 0.45
  Hemodialysis/hemofiltration 14 (10) 8 (9) 0.91
Polymicrobial VAP 34 (25) 29 (33) 0.27
SOFA score at VAP onset 5 (3 to 7) 7 (4 to 9) 0,0004
Adequate antimicrobial treatment* J 0 53 (39) 34 (39) 0.42
  J+1 41 (30) 25 (29) 0.66
  J+2 32 (23) 19 (22) 0.40
Antimicrobials Monotherapy 15 (12) 17 (22) 0.12
  Bi or Tri antibiotic therapy 111 (82) 61 (70) 0.11
  1. Data are the number (%) of patients (minimum to maximum). ICU, intensive care unit; LOD, logistic organ dysfunction; PRPA, piperacillin resistant Pseudomonas aeruginosa; PSPA, piperacillin sensitive Pseudomonas aeruginosa; SAPS II, Simplified Acute Physiology Score version II; SOFA, Simplified Organ Failure Assessment; VAP, ventilator-associated pneumonia.
  2. (*) nb of calendar day between the suspicion of VAP/bacteriological sampling and the initiation of an antimicrobial treatment effective on recovered micro-organisms