Relationship between time to target temperature and outcome in patients treated with therapeutic hypothermia after cardiac arrest

Table 4 Multivariable logistic regression for favorable outcome

	Odds ratio (bootstrapped 95% confidence intervals)	P value
Time to target temperature^a - crude	1.69 (1.22-2.34)	0.002
Time to target temperature^a,b	1.86 (1.03-3.38)	0.04
Time to target temperature adjusted for
Age, years	0.95 (0.92-0.99)	0.01
Epinephrine, mg^c	0.70 (0.46-1.04)	0.08
T_bl cool start, °C^d	1.08 (0.71-1.63)	0.72
1st ECG, VF^e	2.54 (0.84-7.71)	0.10

^aLinear effect for tertiles of time from restoration of spontaneous circulation (ROSC) to esophageal temperature of not more than 34°C (<120, 120 to 220, and >220 minutes). ^bHosmer-Lemeshow chi-squared = 2.67, P = 0.85, indicating good model fit. Temperature data between April 1995 and June 2008 were collected from 588 patients. ^cTotal amount of epinephrine in milligrams needed to achieve ROSC. ^dBladder temperature in degrees Celsius at beginning of cooling. ^eCardiac arrest with ventricular fibrillation or nonperfusing ventricular tachycardia as the initial cardiac rhythm on electrocardiogram.

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