From: Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials
 | Without POD at Day 28 (n= 324) | With POD at Day 28 (n= 113) | Dead by Day 28 (n= 163) | P- value*a |
---|---|---|---|---|
Age | Â | Â | Â | <0.001 bc |
 | 62.6 ± 14.4 | 61.8 ± 13.8 | 67.9 ± 13.5 |  |
Sex | Â | Â | Â | 0.63 |
   Male | 198 (61.1%) | 70 (61.9%) | 93 (57.1%) |  |
   Female | 126 (38.9%) | 43 (38.1%) | 70 (42.9%) |  |
Admission type | Â | Â | Â | <0.001 ab |
   Medical | 233 (71.9%) | 100 (88.5%) | 137 (84.0%) |  |
   Surgical: Elective | 42 (13.0%) | 6 (5.3%) | 8 (4.9%) |  |
   Surgical: Emergency | 49 (15.1%) | 7 (6.2%) | 18 (11.0%) |  |
Primary ICU diagnosis | Â | Â | Â | 0.004 a |
   Cardiovascular/vascular | 29 (9.0%) | 10 (8.8%) | 19 (11.7%) |  |
   Respiratory | 101 (31.2%) | 32 (28.3%) | 49 (30.1%) |  |
   Gastrointestinal | 5 (1.5%) | 2 (1.8%) | 6 (3.7%) |  |
   Neurologic | 3 (0.9%) | 1 (0.9%) | 1 (0.6%) |  |
   Sepsis | 83 (25.6%) | 43 (38.1%) | 54 (33.1%) |  |
   Trauma | 2 (0.6%) | 2 (1.8%) | 1 (0.6%) |  |
   Metabolic | 7 (2.2%) | 1 (0.9%) | 4 (2.5%) |  |
   Hematologic | 1 (0.3%) | 2 (1.8%) | 0 (0.0%) |  |
   Other | 2 (0.6%) | 7 (6.2%) | 3 (1.8%) |  |
   Post-op: Vascular/cardiovascular | 51 (15.7%) | 9 (8.0%) | 10 (6.1%) |  |
   Post-op: Respiratory | 4 (1.2%) | 0 (0.0%) | 2 (1.2%) |  |
   Post-op: Gastrointestinal | 21 (6.5%) | 2 (1.8%) | 10 (6.1%) |  |
   Post-op: Trauma | 4 (1.2%) | 2 (1.8%) | 1 (0.6%) |  |
   Post-op: Renal | 2 (0.6%) | 0 (0.0%) | 0 (0.0%) |  |
   Post-op: Orthopedic | 1 (0.3%) | 0 (0.0%) | 2 (1.2%) |  |
   Post-op:Other | 8 (2.5%) | 0 (0.0%) | 1 (0.6%) |  |
Charleson Comorbidity Index | Â | Â | Â | <0.001 ab |
 | 1.2 ± 1.5 | 1.7 ± 2.0 | 1.7 ± 1.7 |  |
Functional Comorbidity Index | Â | Â | Â | 0.62 |
 | 1.3 ± 1.4 | 1.2 ± 1.4 | 1.4 ± 1.4 |  |
APACHE II | Â | Â | Â | <0.001 ab |
 | 24.4 ± 6.6 | 28.4 ± 5.9 | 29.1 ± 8.0 |  |
Day 1 SOFA score | Â | Â | Â | <0.001 abc |
 | 7.8 ± 2.6 | 9.4 ± 2.8 | 8.7 ± 2.9 |  |
Etiology of shock | Â | Â | Â | 0.16 |
   Cardiogenic | 76 (23.5%) | 20 (17.7%) | 32 (19.6%) |  |
   Septic | 203 (62.7%) | 81 (71.7%) | 112 (68.7%) |  |
   Neurogenic | 3 (0.9%) | 1 (0.9%) | 0 (0.0%) |  |
   Not in shock | 7 (2.2%) | 4 (3.5%) | 2 (1.2%) |  |
   Other | 10 (3.1%) | 2 (1.8%) | 7 (4.3%) |  |
   Hemorrhagic | 15 (4.6%) | 2 (1.8%) | 1 (0.6%) |  |
   Uncertain Origin | 9 (2.8%) | 3 (2.7%) | 9 (5.5%) |  |