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Table 2 Baseline characteristics of patients with and without pod and patients who died by Day 28

From: Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials

 

Without POD at Day 28 (n= 324)

With POD at Day 28 (n= 113)

Dead by Day 28 (n= 163)

P- value*a

Age

   

<0.001 bc

 

62.6 ± 14.4

61.8 ± 13.8

67.9 ± 13.5

 

Sex

   

0.63

   Male

198 (61.1%)

70 (61.9%)

93 (57.1%)

 

   Female

126 (38.9%)

43 (38.1%)

70 (42.9%)

 

Admission type

   

<0.001 ab

   Medical

233 (71.9%)

100 (88.5%)

137 (84.0%)

 

   Surgical: Elective

42 (13.0%)

6 (5.3%)

8 (4.9%)

 

   Surgical: Emergency

49 (15.1%)

7 (6.2%)

18 (11.0%)

 

Primary ICU diagnosis

   

0.004 a

   Cardiovascular/vascular

29 (9.0%)

10 (8.8%)

19 (11.7%)

 

   Respiratory

101 (31.2%)

32 (28.3%)

49 (30.1%)

 

   Gastrointestinal

5 (1.5%)

2 (1.8%)

6 (3.7%)

 

   Neurologic

3 (0.9%)

1 (0.9%)

1 (0.6%)

 

   Sepsis

83 (25.6%)

43 (38.1%)

54 (33.1%)

 

   Trauma

2 (0.6%)

2 (1.8%)

1 (0.6%)

 

   Metabolic

7 (2.2%)

1 (0.9%)

4 (2.5%)

 

   Hematologic

1 (0.3%)

2 (1.8%)

0 (0.0%)

 

   Other

2 (0.6%)

7 (6.2%)

3 (1.8%)

 

   Post-op: Vascular/cardiovascular

51 (15.7%)

9 (8.0%)

10 (6.1%)

 

   Post-op: Respiratory

4 (1.2%)

0 (0.0%)

2 (1.2%)

 

   Post-op: Gastrointestinal

21 (6.5%)

2 (1.8%)

10 (6.1%)

 

   Post-op: Trauma

4 (1.2%)

2 (1.8%)

1 (0.6%)

 

   Post-op: Renal

2 (0.6%)

0 (0.0%)

0 (0.0%)

 

   Post-op: Orthopedic

1 (0.3%)

0 (0.0%)

2 (1.2%)

 

   Post-op:Other

8 (2.5%)

0 (0.0%)

1 (0.6%)

 

Charleson Comorbidity Index

   

<0.001 ab

 

1.2 ± 1.5

1.7 ± 2.0

1.7 ± 1.7

 

Functional Comorbidity Index

   

0.62

 

1.3 ± 1.4

1.2 ± 1.4

1.4 ± 1.4

 

APACHE II

   

<0.001 ab

 

24.4 ± 6.6

28.4 ± 5.9

29.1 ± 8.0

 

Day 1 SOFA score

   

<0.001 abc

 

7.8 ± 2.6

9.4 ± 2.8

8.7 ± 2.9

 

Etiology of shock

   

0.16

   Cardiogenic

76 (23.5%)

20 (17.7%)

32 (19.6%)

 

   Septic

203 (62.7%)

81 (71.7%)

112 (68.7%)

 

   Neurogenic

3 (0.9%)

1 (0.9%)

0 (0.0%)

 

   Not in shock

7 (2.2%)

4 (3.5%)

2 (1.2%)

 

   Other

10 (3.1%)

2 (1.8%)

7 (4.3%)

 

   Hemorrhagic

15 (4.6%)

2 (1.8%)

1 (0.6%)

 

   Uncertain Origin

9 (2.8%)

3 (2.7%)

9 (5.5%)

 
  1. * The global P-value tested against the null hypothesis that all three groups have the same mean or proportion is reported. When the global P-value < 0.05, unadjusted pairwise comparisons were made. Significant (P < 0.05) pairwise comparisons are denoted as follows: a-survivors without POD versus survivors with POD, b-survivors without POD versus decedents, c-survivors with POD versus decedents.
  2. APACHE II, Acute Physiology and Chronic Health Evaluation; ICU, Intensive Care Unit; POD, Persistent Organ Dysfunction Score; SOFA, Sequential Organ Failure Assessment.