|  | International units relative to factor IX |  |  | |||
---|---|---|---|---|---|---|---|
Brand name | Manufacturer | Factor II | Factor VII | Factor IX | Factor X | Viral inactivation | Additional information |
Bebulin VH | Baxter BioScience, Austria | 120 | (13) | 100 | 100 | Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for 1 hour at 375 mbar | Heparin added |
Beriplex P/N | CSL Behring, Germany | 128 | 68 | 100 | 152 | Pasteurisation at 60°C for 10 hours, and nanofiltration | Protein C; antithrombin, heparin and albumin added |
Cofact | Sanquin, the Netherlands | 56-140 | 28-80 | 100 | 56-140 | Solvent/detergent and 15 nm nanofiltration | Antithrombin added |
KASKADIL | LFB, France | 148 | 40 | 100 | 160 | Solvent/detergent | Heparin added |
Octaplex | Octapharma, Austria and France | 44-152 | 36-96 | 100 | 50 | Solvent/detergent and nanofiltration | Heparin added; low activated factor VII content |
Profilnine SD | Grifols, USA | 148 | (11) | 100 | 64 | Solvent/detergent | - |
Prothrombinex VF | CSL Bioplasma, Australia | 100 | (-) | 100 | 100 | Dry heat, 80°C for 72 hours and nanofiltration | Antithrombin and heparin added |
Prothromplex T | Baxter BioScience, Austria | 100 | 85 | 100 | 100 | Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for 1 hour at 375 mbar | Antithrombin and heparin added |
UMAN Complex D.I. | Kedrion, Italy | 100 | (-) | 100 | 80 | Solvent/detergent and dry heat, 100°C for 30 minutes | Antithrombin and heparin added |