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Table 2 Characteristics of acute respiratory failurea

From: Acute respiratory failure in kidney transplant recipients: a multicenter study

Patient characteristics

All patients (N= 200)

Hospital survivors (n= 155)

Hospital deaths (n= 45)

P value

Median time from transplantation to ICU admission, months (25th to 75th percentile)

17 (3 to 67.3)

17 (2 to 65)

15 (3 to 98)

0.69

Median time from acute rejection to ICU admission, months (25th to 75th percentile) (n = 43 patients)

9.6 (2.8 to 23.8)

16.2 (3.6 to 40.8)

2.4 (0.4 to 7.2)

0.026

Median time from dyspnea onset to ICU admission, days (25th to 75th percentile)

2 (1 to 6)

2 (1 to 6)

2 (0 to 7)

0.97

Median time from hospital to ICU admission, days (25th to 75th percentile)

3 (0 to 10)

2 (0 to 9)

3 (0 to 13)

0.69

Median body temperature at ICU admission (25th to 75th percentile)

38.5°C (37.2°C to 39.1°C)

38.5°C (37.2°C to 39.1°C)

38.5°C (37.2°C to 39.0°C)

0.57

PaO2/FiO2 ratio, n (%)

   

0.14

   > 300

19 (10.9)

18 (13)

1 (3)

 

   200-300

47 (26.9)

36 (27)

11 (28)

 

   ≤ 200

109 (62.3)

81 (60)

28 (70)

 

ICU admission directly from the emergency room, n (%)

61 (30.5)

46 (30)

15 (33)

0.71

Oxygen flow (L/minute) at ICU admission (25th to 75th percentile)

10 (6 to 15)

8 (5 to 15)

15 (6 to 15)

0.041

Serum creatinine (μM/L) at ICU admission (25th to 75th percentile)

250 (156 - 382)

255 (160 - 393)

240 (150 - 332)

0.23

Shock at ICU admission, n (%)

69 (34.8)

40 (26)

29 (64)

< 0.0001

Need for life-sustaining treatments throughout ICU stay, n (%)

   

< 0.0001

   Respiratory support

    

Oxygen only

77 (38.5)

75 (48)

2 (4)

 

NIV

30 (15)

26 (17)

4 (9)

 

NIV followed by invasive mechanical ventilation

34 (17)

23 (15)

11 (24)

 

First-line invasive mechanical ventilation

59 (29.5)

31 (20)

28 (62)

 

Vasopressors

82 (41)

42 (27)

40 (89)

< 0.0001

   Renal replacement therapy

104 (52)

70 (45)

34 (76)

0.0006

Median SOFA score, day 1

7 (5 to 10)

6 (4 to 8)

11 (7 to 14)

< 0.0001

Median SOFA score, day 2

6 (4 to 10)

5 (4 to 7)

12 (7 to 15)

< 0.0001

Median SOFA score, day 3

5 (4 to 8)

5 (3 to 6)

12 (7 to 15)

< 0.0001

Median length of ICU stay, days

6 (3 to 12)

5 (3 to 10)

8 (3 to 15)

0.25

Median length of hospital stay, days

22 (13 to 41)

22 (14 to 43)

23 (8 to 40)

0.27

  1. aICU, intensive care unit; PaO2/FiO2 ratio, ratio of partial pressure of arterial oxygen to fraction of inspired oxygen; NIV, noninvasive mechanical ventilation; SOFA score, Sequential Organ Failure Assessment score.