From: Acute respiratory failure in kidney transplant recipients: a multicenter study
Patient characteristics | All patients (N= 200) | Hospital survivors (n= 155) | Hospital deaths (n= 45) | P value |
---|---|---|---|---|
Median time from transplantation to ICU admission, months (25th to 75th percentile) | 17 (3 to 67.3) | 17 (2 to 65) | 15 (3 to 98) | 0.69 |
Median time from acute rejection to ICU admission, months (25th to 75th percentile) (n = 43 patients) | 9.6 (2.8 to 23.8) | 16.2 (3.6 to 40.8) | 2.4 (0.4 to 7.2) | 0.026 |
Median time from dyspnea onset to ICU admission, days (25th to 75th percentile) | 2 (1 to 6) | 2 (1 to 6) | 2 (0 to 7) | 0.97 |
Median time from hospital to ICU admission, days (25th to 75th percentile) | 3 (0 to 10) | 2 (0 to 9) | 3 (0 to 13) | 0.69 |
Median body temperature at ICU admission (25th to 75th percentile) | 38.5°C (37.2°C to 39.1°C) | 38.5°C (37.2°C to 39.1°C) | 38.5°C (37.2°C to 39.0°C) | 0.57 |
PaO2/FiO2 ratio, n (%) | 0.14 | |||
> 300 | 19 (10.9) | 18 (13) | 1 (3) | |
200-300 | 47 (26.9) | 36 (27) | 11 (28) | |
≤ 200 | 109 (62.3) | 81 (60) | 28 (70) | |
ICU admission directly from the emergency room, n (%) | 61 (30.5) | 46 (30) | 15 (33) | 0.71 |
Oxygen flow (L/minute) at ICU admission (25th to 75th percentile) | 10 (6 to 15) | 8 (5 to 15) | 15 (6 to 15) | 0.041 |
Serum creatinine (μM/L) at ICU admission (25th to 75th percentile) | 250 (156 - 382) | 255 (160 - 393) | 240 (150 - 332) | 0.23 |
Shock at ICU admission, n (%) | 69 (34.8) | 40 (26) | 29 (64) | < 0.0001 |
Need for life-sustaining treatments throughout ICU stay, n (%) | < 0.0001 | |||
Respiratory support | ||||
Oxygen only | 77 (38.5) | 75 (48) | 2 (4) | |
NIV | 30 (15) | 26 (17) | 4 (9) | |
NIV followed by invasive mechanical ventilation | 34 (17) | 23 (15) | 11 (24) | |
First-line invasive mechanical ventilation | 59 (29.5) | 31 (20) | 28 (62) | |
Vasopressors | 82 (41) | 42 (27) | 40 (89) | < 0.0001 |
Renal replacement therapy | 104 (52) | 70 (45) | 34 (76) | 0.0006 |
Median SOFA score, day 1 | 7 (5 to 10) | 6 (4 to 8) | 11 (7 to 14) | < 0.0001 |
Median SOFA score, day 2 | 6 (4 to 10) | 5 (4 to 7) | 12 (7 to 15) | < 0.0001 |
Median SOFA score, day 3 | 5 (4 to 8) | 5 (3 to 6) | 12 (7 to 15) | < 0.0001 |
Median length of ICU stay, days | 6 (3 to 12) | 5 (3 to 10) | 8 (3 to 15) | 0.25 |
Median length of hospital stay, days | 22 (13 to 41) | 22 (14 to 43) | 23 (8 to 40) | 0.27 |