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Table 2 Characteristics of patients with septic shock in the entire study cohort and propensity-matched sample

From: Activated protein C in septic shock: a propensity-matched analysis

  Overall
n= 563
n (%)
Treated
matched
n= 108
n (%)
Untreated
matched
n= 108
n (%)
P a
Patient characteristics     
   Age in yrs, mean, SD c 67.1(15.5) 62.9 (17.2) 64.2 (16.1) 0.53
   Male c 284 (50.4) 60 (55.6) 57 (52.8) 0.64
   Body mass index, mean, SD c 28.0 (8.6) 27.3 (7.8) 27.8 (7.5) 0.66
   APACHE II, mean, SD c 24.8 (8.3) 24.5 (8.4) 23.9 (8.3) 0.54
Comorbidities     
   Congestive heart failure c 86 (15.3) 10 (9.2) 15 (13.9) 0.28
   Diabetes c 172 (30.5) 25 (23.2) 20 (18.5) 0.40
   Hypertension c 320 (56.9) 51(47.2) 53 (49.1) 0.76
   Chronic pulmonary disease c 266 (47.3) 42 (38.9) 40 (37.0) 0.77
   Neurologic disease c 8 (1.4) 1(0.9) 0 (0) 1.00
   Chronic kidney disease c 132 (23.5) 22 (20.4) 24 (22.2) 0.73
   Cancer c 121(21.5) 7 (6.5) 7 (6.5) 1.00
   Chronic liver disease c 36 (6.4) 10 (9.3) 8 (7.4) 0.62
   Chronic pancreatitis c 3 (0.5) 1(0.9) 1(0.9) 1.00
Organ failure     
   Kidney c 161(28.6) 33 (30.6) 34 (31.5) 0.88
   Respiratory c 296 (52.6) 61 (56.5) 61 (56.5) 1.00
   Hematologic c 214 (38.0) 52 (48.1) 49 (45.4) 0.67
   Metabolic/lactic acidosis c 262 (46.5) 60 (55.6) 60 (55.6) 1.00
Number of organ failures     
   1 104 (18.5) 13 (12.0) 12 (11.1)  
   2 169 (30.0) 30 (27.8) 32 (29.6)  
   3 147 (26.1) 30 (27.8) 32 (29.6) 0.97b
   4 102 (18.1) 24 (22.2) 20 (18.5)  
   5 41 (7.3) 11 (10.2) 12 (11.1)  
Inotrope c 123 (21.9) 30 (27.8) 32 (29.6) 0.77
Steroid c 219 (38.9) 50 (46.3) 46 (42.6) 0.59
Insulin drip c 153 (27.2) 37 (34.3) 32 (29.7) 0.46
Statins c 65 (11.6) 19 (17.6) 16 (14.8) 0.59
Chemical DVT prophylaxis c 319 (56.7) 76 (70.4) 74 (68.5) 0.77
Sepsis source     
   Abdomen 86 (15.3) 12 (11.1) 20 (18.5)  
   Blood 34 (6.0) 9 (8.3) 3 (2.8)  
   Lung 251 (44.6) 54 (50.0) 42 (38.9) 0.08b
   Urinary Tract 101 (17.9) 20 (18.5) 22 (20.4)  
   Other/unknown 91 (16.2) 13 (12.0) 21 (19.4)  
  1. a The P- value for treated matched vs. untreated matched adjusted for matching by propensity.
  2. b P-values, one for the number of organ failures, and one for sepsis source, because each test is being done as a chi-square test on a 2 × 5 crosstable.
  3. c The 22 variables used in the propensity matching.
  4. Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; DVT, deep vein thrombosis; P, P-value; SD, standard deviation; yrs, years.