Table 2 Characteristics of patients with septic shock in the entire study cohort and propensity-matched sample
From: Activated protein C in septic shock: a propensity-matched analysis
Overall n= 563 n (%) | Treated matched n= 108 n (%) | Untreated matched n= 108 n (%) | P a | |
|---|---|---|---|---|
Patient characteristics | ||||
Age in yrs, mean, SD c | 67.1(15.5) | 62.9 (17.2) | 64.2 (16.1) | 0.53 |
Male c | 284 (50.4) | 60 (55.6) | 57 (52.8) | 0.64 |
Body mass index, mean, SD c | 28.0 (8.6) | 27.3 (7.8) | 27.8 (7.5) | 0.66 |
APACHE II, mean, SD c | 24.8 (8.3) | 24.5 (8.4) | 23.9 (8.3) | 0.54 |
Comorbidities | ||||
Congestive heart failure c | 86 (15.3) | 10 (9.2) | 15 (13.9) | 0.28 |
Diabetes c | 172 (30.5) | 25 (23.2) | 20 (18.5) | 0.40 |
Hypertension c | 320 (56.9) | 51(47.2) | 53 (49.1) | 0.76 |
Chronic pulmonary disease c | 266 (47.3) | 42 (38.9) | 40 (37.0) | 0.77 |
Neurologic disease c | 8 (1.4) | 1(0.9) | 0 (0) | 1.00 |
Chronic kidney disease c | 132 (23.5) | 22 (20.4) | 24 (22.2) | 0.73 |
Cancer c | 121(21.5) | 7 (6.5) | 7 (6.5) | 1.00 |
Chronic liver disease c | 36 (6.4) | 10 (9.3) | 8 (7.4) | 0.62 |
Chronic pancreatitis c | 3 (0.5) | 1(0.9) | 1(0.9) | 1.00 |
Organ failure | ||||
Kidney c | 161(28.6) | 33 (30.6) | 34 (31.5) | 0.88 |
Respiratory c | 296 (52.6) | 61 (56.5) | 61 (56.5) | 1.00 |
Hematologic c | 214 (38.0) | 52 (48.1) | 49 (45.4) | 0.67 |
Metabolic/lactic acidosis c | 262 (46.5) | 60 (55.6) | 60 (55.6) | 1.00 |
Number of organ failures | ||||
1 | 104 (18.5) | 13 (12.0) | 12 (11.1) | |
2 | 169 (30.0) | 30 (27.8) | 32 (29.6) | |
3 | 147 (26.1) | 30 (27.8) | 32 (29.6) | 0.97b |
4 | 102 (18.1) | 24 (22.2) | 20 (18.5) | |
5 | 41 (7.3) | 11 (10.2) | 12 (11.1) | |
Inotrope c | 123 (21.9) | 30 (27.8) | 32 (29.6) | 0.77 |
Steroid c | 219 (38.9) | 50 (46.3) | 46 (42.6) | 0.59 |
Insulin drip c | 153 (27.2) | 37 (34.3) | 32 (29.7) | 0.46 |
Statins c | 65 (11.6) | 19 (17.6) | 16 (14.8) | 0.59 |
Chemical DVT prophylaxis c | 319 (56.7) | 76 (70.4) | 74 (68.5) | 0.77 |
Sepsis source | ||||
Abdomen | 86 (15.3) | 12 (11.1) | 20 (18.5) | |
Blood | 34 (6.0) | 9 (8.3) | 3 (2.8) | |
Lung | 251 (44.6) | 54 (50.0) | 42 (38.9) | 0.08b |
Urinary Tract | 101 (17.9) | 20 (18.5) | 22 (20.4) | |
Other/unknown | 91 (16.2) | 13 (12.0) | 21 (19.4) |