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Table 1 Definitions of organ failures

From: Activated protein C in septic shock: a propensity-matched analysis

Organ Definition
Cardiovascular Blood pressure criteria are present for at least one hour despite adequate fluid resuscitation; arterial systolic BP <90 mmHg OR Arterial systolic BP with 40 mmHg drop from baseline OR mean arterial pressure (MAP) <70 mmHg, and vasopressors are required to maintain BP >90 mmHg systolic or MAP >70
Metabolic Serum lactate elevated >upper limits per lab
Renal Serum creatinine increased by more than 1 mg/dl from baseline after adequate fluid resuscitation OR serum creatinine > = 2 mg/dl, in the absence of known baseline a
Respiratory PaO2/FiO2 < = 300 OR requires PEEP >5 cm H2Ob
Hematologic Platelet count is half the highest value in the last three days OR Platelets <100,000/mm3 OR PT/PTT >1.5 times controlc
  1. a Does not apply to patients on chronic hemodialysis.
  2. b Criteria apply to acute lung injury, not CHF or cardiogenic pulmonary edema.
  3. c Not due to anticoagulant therapy.
  4. Abbreviations: BP, blood pressure; mmHG, millimeters of mercury; mg, milligram; dl, deciliter; PaO2, partial pressure of oxygen in arterial blood; FiO2, fraction of inspired oxygen; PEEP, positive end-expiratory pressure; PT, prothrombin time; PTT, partial thromboplastin time.