Table 1 Definitions of organ failures

Cardiovascular

Blood pressure criteria are present for at least one hour despite adequate fluid resuscitation; arterial systolic BP <90 mmHg OR Arterial systolic BP with 40 mmHg drop from baseline OR mean arterial pressure (MAP) <70 mmHg, and vasopressors are required to maintain BP >90 mmHg systolic or MAP >70

Metabolic

Serum lactate elevated >upper limits per lab

Renal

Serum creatinine increased by more than 1 mg/dl from baseline after adequate fluid resuscitation OR serum creatinine > = 2 mg/dl, in the absence of known baseline ^a

Respiratory

PaO2/FiO2 < = 300 OR requires PEEP >5 cm H2O^b

Hematologic

Platelet count is half the highest value in the last three days OR Platelets <100,000/mm³ OR PT/PTT >1.5 times control^c