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Table 3 Predictive performance of ΔRESPPP according to chosen cutoff and fluid responsiveness definitiona

From: Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome

Definition of fluid responsiveness Increase in CO >10% after volume expansion Increase in CO >15% after volume expansion Increase in CO >300 ml/min/m2 after volume expansion
AUC for ΔRESPPP 0.75 (0.62 to 0.85) 0.75 (0.63 to 0.85) 0.76 (0.63 to 0.84)
Cutoff for ΔRESPPP 12% 5%b 12% 5%b 12% 4%b
LR+ 2
(0.8 to 4.9)
4.8
(3.6 to 6.2)
2.8
(1.2 to 6.8)
3.7
(2.8 to 4.9)
4.5
(2.2 to 9.5)
3.5
(2.6 to 4.7)
LR- 0.92
(0.3 to 2.8)
0.32
(0.1 to 0.8)
0.87
(0.3 to 2.6)
0.30
(0.1 to 0.8)
0.87
(0.1 to 6.0)
0.46
(0.2 to 1.1)
Se 0.15
(0.05 to 0.35)
0.73
(0.52 to 0.88)
0.19
(0.06 to 0.42)
0.76
(0.53 to 0.92)
0.16
(0.06 to 0.32)
0.62
(0.45 to 0.78)
Sp 0.92
(0.79 to 0.98)
0.85
(0.70 to 0.94)
0.93
(0.81 to 0.99)
0.80
(0.65 to 0.90)
0.96
(0.82 to 0.99)
0.82
(0.63 to 0.94)
PPV 0.57
(0.20 to 0.88)
0.76
(0.54 to 0.90)
0.57
(0.20 to 0.88)
0.64
(0.43 to 0.81)
0.86
(0.42 to 0.98)
0.82
(0.63 to 0.94)
NPV 0.62
(0.48 to 0.74)
0.83
(0.67 to 0.92)
0.71
(0.57 to 0.82)
0.88
(0.72 to 0.95)
0.47
(0.33 to 0.60)
0.62
(0.45 to 0.7)
  1. aCO, cardiac output; AUC, area under the receiver operating characteristic curve; ΔRESPPP, respiratory changes in pulse pressure; LR+, positive likelihood ratio; LR-, negative likelihood ratio; Se, sensitivity; Sp, specificity; PPV; positive predictive value; NPV, negative predictive value; bbest cutoff identified in our study population. Ranges in parentheses represent 95% confidence intervals.