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Table 1 Entry and exclusionary criteria

From: Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial

Age 18 years or older
Adequate gas exchange as indicated by a PaO2 above 60 mmHg while breathing with an FIO2 of 0.50 or less
Be medically stable and ready to be weaned from the ventilator as determined by the attending physician
Hemodynamically stable for 24 hours prior to participation or requiring only minimal intravenous pressor agents (dobutamine or dopamine ≤ 5 mcg/kg/min, phenyleprine ≤ 1 mcg/kg/min)
Be able to follow simple verbal directions related to inspiratory muscle strength testing and training
Receiving assist control or SIMV or pressure support ventilation via a tracheostomy, with SIMV ≤ 6 breaths/min, pressure support ventilation ≤ 15 cm H2O and PEEP ≤ 10 cmH2O
Unable to sustain unsupported breathing for at least 72 consecutive hours following resolution of factor(s) precipitating respiratory failure
Demonstrate normal hemidiaphragm positions on X-ray
Not have any progressive neuromuscular disease such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis, or any other neuromuscular disorder that would interfere with responding to inspiratory muscle training
Have an anticipated life expectancy of at least 12 months
Have a core temperature between ≥36.5°C and ≤ 38.5°C
Not have a spinal cord injury above T8
Not have any skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs
Not using any type of home MV support prior to hospitalization
Body mass index < 40 kg/m2
Not require continuous sedative or analgesic agents that will depress respiratory drive or the ability to follow commands
No excessive secretions (requiring suctioning more than once every hour)
Not being considering for transfer to another hospital in the next
28 days
  1. FiO2, fraction of inspired oxygen; MV, mechanical ventilation; PaO2, arterial pressure of oxygen; PEEP, positive end expiratory pressure; SIMV, synchronized intermittent mandatory ventilation.