Extracorporeal cell therapy of septic shock patients with donor granulocytes: a pilot study

Table 3 Changes in cytokine concentrations in patients' bood (left side) and in the extracorporeal circuit (right side).

	Patient				Extracorporeal circuit during treatment
Mediator	Before extracorporeal treatment	After 6 h extracorporeal treatment	%	P	Directly before cell compartment	Directly behind cell compartment	%	P
IL-2	3.67	11.92	325	n.s.	0.78	1.42	182	< 0.05
IL-4	0.87	2.29	263	n.s.	0.09	0.24	268	<0.001
IL-6	102.22	313.15	306	n.s.	226.06	299.38	132	n.s.
IL-8	20.39	41.31	203	<0.05	31.79	165.15	520	<0.001
IL-10	2.57	6.54	254	<0.01	3.86	6.02	156	<0.05
IL-1 beta	1.21	2.12	175	<0.05	0.74	1.11	150	<0.05
IL-5	0.42	1.33	315	n.s.	0.39	0.52	135	n.s.
IL-7	3.19	5.19	163	n.s.	2.64	4.14	157	n.s.
IL-12(p70)	2.46	9.65	392	n.s.	0.09	0.45	498	<0.001
IL-13	1.68	3.34	199	n.s.	0.85	1.05	124	n.s.
IL-17	0.05	0.59	1185	n.s.	0.04	0.10	274	n.s.
IL-1ra	106.96	208.03	194	n.s.	113.40	134.53	119	n.s.
IL-15	4.19	6.35	151	n.s.	3.20	4.37	136	n.s.
IL-9	1.11	8.15	737	n.s.	0.29	0.78	265	n.s.
IP-10	240.16	561.57	234	n.s.	508.51	749.08	147	<0.05
G-CSF	30.84	43.73	142	n.s.	50.87	53.44	105	n.s.
GM-CSF	10.81	50.79	470	n.s.	1.52	3.41	224	n.s.
IFN gamma	50.29	79.07	157	n.s.	14.83	25.26	170	<0.05
TNF alpha	0.00	0.00	100	n.s.	0.81	0.19	24	n.s.
MCP-1(MCAF)	130.72	224.46	172	n.s.	299.52	225.67	75	n.s.
MIP-1b	55.93	98.89	177	n.s.	76.92	103.23	134	n.s.
Eotaxin	85.64	216.82	253	<0.05	80.23	130.72	163	<0.01
FGF basic	1.51	9.47	629	n.s.	0.61	0.00	0	n.s.
PDGF bb	652.01	1145.02	176	n.s.	10.28	62.25	606	<0.001
RANTES	137.70	298.64	217	<0.05	22.91	141.43	617	<0.001
VEGF	168.92	198.68	118	n.s.	1.12	2.45	219	n.s.
MIP-1 alpha	0.39	1.00	253	n.s.	0.34	0.51	148	n.s.

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