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Table 3 Factors associated with 30-day pneumonia-related mortality in patients with ICU-acquired pneumonia determined by multivariable analysisa

From: Impact of de-escalation therapy on clinical outcomes for intensive care unit-acquired pneumonia

Variable

Adjusted hazard ratiob

95% CI

P value

Inadequacy of antibiotics

2.145

0.483 to 9.536

0.316

Non-de-escalation of antibiotics

3.988

0.047 to 6.985

0.245

Baseline APACHE II score (reference score <19)

  

0.198

   20 to 23

2.528

0.609 to 10.493

0.201

   ≥24

7.611

0.615 to 94.179

0.114

5-day APACHE II score (reference score <19)

  

0.011

   20 to 23

4.934

0.974 to 25.003

0.054

   ≥24

12.839

2.359 to 69.883

0.003

5-day CPIS (reference score 4 to 6)

  

0.017

   7 to 9

2.154

0.361 to 12.861

0.400

   ≥10

26.782

2.180 to 329.011

0.010

  1. aICU, intensive care unit; 95% CI, 95% confidence interval; APACHE II, Acute Physiology and Chronic Health Evaluation II; CPIS, Clinical Pulmonary Infection Score; bCox proportional hazard regression analysis was used to determine the relationship between mortality and independent baseline variables identified in univariable analysis, including inadequacy of initial antibiotics, de-escalation of antibiotics, baseline APACHE II score, 5-day APACHE II score and 5-day CPIS.