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Table 3 Factors associated with 30-day pneumonia-related mortality in patients with ICU-acquired pneumonia determined by multivariable analysisa

From: Impact of de-escalation therapy on clinical outcomes for intensive care unit-acquired pneumonia

Variable Adjusted hazard ratiob 95% CI P value
Inadequacy of antibiotics 2.145 0.483 to 9.536 0.316
Non-de-escalation of antibiotics 3.988 0.047 to 6.985 0.245
Baseline APACHE II score (reference score <19)    0.198
   20 to 23 2.528 0.609 to 10.493 0.201
   ≥24 7.611 0.615 to 94.179 0.114
5-day APACHE II score (reference score <19)    0.011
   20 to 23 4.934 0.974 to 25.003 0.054
   ≥24 12.839 2.359 to 69.883 0.003
5-day CPIS (reference score 4 to 6)    0.017
   7 to 9 2.154 0.361 to 12.861 0.400
   ≥10 26.782 2.180 to 329.011 0.010
  1. aICU, intensive care unit; 95% CI, 95% confidence interval; APACHE II, Acute Physiology and Chronic Health Evaluation II; CPIS, Clinical Pulmonary Infection Score; bCox proportional hazard regression analysis was used to determine the relationship between mortality and independent baseline variables identified in univariable analysis, including inadequacy of initial antibiotics, de-escalation of antibiotics, baseline APACHE II score, 5-day APACHE II score and 5-day CPIS.