Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients

Table 2 Inflammatory biomarkers and outcomes

	Inflammatory Biomarker Odds Ratio (95% Confidence Intervals)*‡
Outcome	Procalcitonin	C-reactive protein
Delirium/coma-free days	0.5 (0.3, 1.0)	0.6 (0.3, 1.1)
28-day survival ^†	1.4 (0.7, 2.9)	1.7 (0.8, 3.4)
Kidney-dysfunction free days	0.7 (0.3, 1.3)	---
Septic	---	0.3 (0.1, 0.6)
Non-Septic	---	2.6 (0.5, 12.4)
Lung-dysfunction free days	1.0 (0.5, 1.9)	0.4 (0.2, 0.8)
Liver-dysfunction free days	1.1 (0.5, 2.3)	0.9 (0.4, 1.9)
Coagulation-dysfunction free days	1.0 (0.5, 1.9)
Septic	---	1.1 (0.4, 2.6)
Non-Septic	---	2.1 (0.3, 14.9)
Hemodynamic-dysfunction free days	0.4 (0.2, 0.8)	---
Septic	---	0.6 (0.2, 1.4)
Non-Septic	---	12.4 (0.7, 229.8)
Cardiac-dysfunction free days	0.6 (0.3, 1.3)
Septic	---	0.7 (0.3, 1.5)
Non-Septic	---	3.0 (0.5, 16.6)

*All reported ratios compare the odds or hazard of the outcome (for example, more dysfunction-free days) among patients at the 75^th percentile of the biomarker levels of our population to patients at the 25^th percentile. This is a more clinically relevant comparison than a one-unit change in biomarker and allows for some description of nonlinear association.
‡We assessed for interactions between the presence of sepsis and the association of the biomarkers with each organ dysfunction outcome. A single odds ratio is presented when sepsis did not affect the association of the biomarker with the outcome. If a significant interaction with sepsis existed, however, then two separate odds ratios are presented to show the different associations between the biomarker and the organ dysfunction, depending on the presence of sepsis.
†Hazard ratios are presented for 28-day survival.

ISSN: 1364-8535