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Table 4 Cox regression analyses of factors associated with LOS in the ICU of the 86 included patients

From: Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis

  Univariable analysis Multivariable analysis
Factor HR P-v alue HR 95% CI P-v alue
CMV reactivation 3.101 0.009 3.365 1.233 to 9.183 0.018
SAPS II at inclusion 1.065 <0.001 1.045 1.008 to 1.083 0.016
Septic Shock present 2.282 0.081 1.486 0.535 to 4.127 0.447
ICU stay before enrolment 1.006 0.577 1.020 0.996 to 1.044 0.104
HSV detection in respiratory secretions 1.302 0.501 1.338 0.595 to 3.013 0.481
Optimized model
CMV reactivation    2.441 1.011 to 5.897 0.047
SAPS II at inclusion    1.055 1.020 to 1.091 0.002
Landmark analysis for Day 0, Day 7 and Day 14
Day 0 (86 patients, 12 of them with CMV reactivation)
   CMV reactivation 1.017 0.975 1.061 0.367 to 3.068 0.913
   SAPS II at inclusion 1.065 <0.001 1.065 1.030 to 1.101 <0.001
Day 7 (64 patients, 16 of them with CMV reactivation)
   CMV reactivation 2.274 0.112 2.853 1.003 to 8.117 0.049
   SAPS II at inclusion 1.071 0.001 1.074 1.033 to 1.116 <0.001
Day 14 (47 patients, 17 of them with CMV reactivation)
   CMV reactivation 2.109 0.164 2.538 0.861 to 7.479 0.091
   SAPS II at inclusion 1.065 0.010 1.069 1.021 to 1.120 0.004
  1. CI, confidence interval; CMV, cytomegalovirus; HR, hazard ratio; HSV, herpes simplex virus; LOS, length of stay; SAPS, Sequential Organ Failure Assessment score.