Figure 1From: Prediction of fluid challenge effect: filling pressure when left ventricular function is abnormal, diastolic volume when left ventricular function is normalSimplification of the right and left stroke volume variations during mechanical ventilation. (a) During insufflation, the right ventricular afterload increases with venous return impairment leading to a reduced stroke volume (SV). Simultaneously, lung squeezing pushes blood towards the left ventricle, creating a better left ventricular preload and then a better SV. As a consequence, the pulmonary blood volume decreases. (b) During exsufflation, the right ventricle works with a reduced afterload and a better preload, ejecting a higher SV. In addition, the lung is engorged according to pulmonary vessel compliance, storing blood and reducing preload of the left ventricle and its SV. As a consequence, the pulmonary blood volume increases. Globally, insufflation reduces the pulmonary blood volume when exsufflation is increasing it. MV, mechanical ventilation.Back to article page