Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study

Table 3 Predictors of acute organ failure occurring on or after the first day of statin administration

Variable (n= 1,319) ^a	Univariable analyses			Multivariable analyses
	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value
Statin versus no statin	1.40	1.06 to 1.84	0.016	1.22	0.92 to 1.62	0.17
Age^b	1.008	1.00 to 1.01	0.007	1.00	0.99 to 1.01	0.68
Admission APACHE II score^b	1.054	1.04 to 1.07	< 0.0001	1.05	1.03 to 1.07	< 0.0001
APACHE II admission category (reference level: respiratory)			< 0.0001			< 0.0001
Cardiovascular	1.39	1.11 to 1.75	0.005	1.34	1.06 to 1.69	0.015
Gastrointestinal	0.91	0.61 to 1.36	0.64	0.97	0.65 to 1.45	0.89
Neurological	0.45	0.31 to 0.66	< 0.0001	0.48	0.33 to 0.71	0.0002
Gender (female)	0.98	0.79 to 1.22	0.85	0.95	0.76 to 1.18	0.65
Total baseline SOFA^b	1.097	1.03 to 1.17	0.005	1.002	0.94 to 1.07	0.95

APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; SOFA, Sequential Organ Failure Assessment. ^aSeventy-eight patients were excluded from the model: 61 patients with missing data on at least one of the variables included in the model, and 17 patients who have the APACHE II admission category of metabolic, of whom only one was in the statin group. ^bOdds ratios per one-unit increase.

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