Skip to main content

Table 1 Baseline characteristics

From: Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study

Variable

Overall (n= 1,397)

No statin exposure (n= 1,178)

Statin exposed (n= 219)

P value

Age (years)

57.4 (18.4)

55.5 (18.9)

67.4 (10.3)

< 0.0001

APACHE II score

18.2 (6.8)

17.8 (6.9)a

20.3 (6.0)

< 0.0001

Female

501 (35.9%)

446 (37.9%)

55 (25.11%)

0.0003

Reason for admissionb

   

< 0.0001

   Infection

320 (22.9%)

269 (22.9%)

51 (23.3%)

 

   Sepsis/septic shock

44 (3.2%)

39 (3.3%)

5 (2.3%)

 

   Cardiac failure

31 (2.2%)

16 (1.4%)

15 (6.9%)

 

   Haemorrhage

48 (3.4%)

46 (3.9%)

2 (0.9%)

 

   Postoperative ventilation (planned)

176 (12.6%)

147 (12.5%)

29 (13.2%)

 

   Postoperative ventilation (unplanned)

149 (10.7%)

112 (9.5%)

37 (16.9%)

 

   Otherc

628 (45.0%)

548 (46.6%)

80 (36.5%)

 

Number of statin doses received

  

3 (2, 8)

 

Main admission categoryd

   

< 0.0001

   Cardiovascular

464 (34.3%)

347 (30.5%)

117 (54.4%)

 

   Gastrointestinal

118 (8.7%)

110 (9.7%)

8 (3.7%)

 

   Metabolic

17 (1.3%)

16 (1.4%)

1 (0.5%)

 

   Neurological

302 (22.3%)

286 (25.2%)

16 (7.4%)

 

   Respiratory

451 (33.4%)

378 (33.2%)

73 (33.95%)

 

Admission source

   

< 0.0001

   Emergency room

369 (26.4%)

326 (27.7%)

43 (19.6%)

 

   Hospital ward

221 (15.8%)

175 (14.9%)

46 (21%)

 

   Another hospital

294(21.05%)

263 (22.3%)

31 (14.2%)

 

   Operating room

377(26.99%)

310 (26.3%)

67 (30.6%)

 

   High dependency ward

125 (8.95%)

98 (8.3%)

27 (12.3%)

 

Other

11 (0.79%)

6 (0.51%)

5 (2.3%)

 

Baseline biochemistry

    

   Bilirubin (mmol/l)

17 (12, 25)

17 (12, 26)e

17 (12, 23)

0.31

   ALT (IU/l)

25 (15, 48.5)

24 (15, 46)f

34 (18, 64)

< 0.0001

Baseline SOFA

    

   Total

3 (2, 4)

3 (2, 4)

4 (3, 5)

< 0.0001

   Median total nonrespiratory

1 (0, 2)

1 (0, 2)

1 (0, 2)

0.0005

   Mean total nonrespiratory

1.23 ± 1.29

1.18 ± 1.28

1.49 ± 1.31

0.001

   Respiratory:

   

< 0.0001

0

70 (5.01%)

62 (5.3%)

8 (3.6%)

 

1 or 2

973 (69.7%)

843 (71.6%)

130 (59.4%)

 

3 or 4

354 (25.3%)

273 (23.2%)

81 (37.0%)

 

   Hepatic 1 or 2

591 (42.3%)

503 (42.7%)

88 (40.2%)

0.49

   Renal 1 or 2

328 (23.5%)

243 (20.6%)

85 (38.8%)

< 0.0001

   Haematological 1 or 2

341 (24.4%)

284 (24.1%)

57 (26.0%)

0.54

   Cardiovascular 1 or 2

28 (2%)

14 (1.2%)

14 (6.4%)

< 0.0001

  1. Data expressed as mean ± standard deviation, median (interquartile range), or number (percentage). ALT, alanine transferase; APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment. aData missing for 16 patients. bData missing for one patient. cInclude trauma (n = 44, 3.2%), overdose (n = 96, 6.9%), seizures (n = 84, 6.0%), post-arrest (n = 117, 8.4%) and abdominal obstruction or perforation (n = 54, 3.9%). dData missing for 41 patients in the nonstatin group and four patients in the statin group. eData missing for 20 patients. fData missing for 21 patients.
Back to article page

Critical Care

ISSN: 1364-8535