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Table 2 Adjusted odds ratios for 24-hour survival and good neurological outcome from binary logistic regression analysis

From: Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis

 

24-hour survival

Good neurological outcome

 

OR (95% CI)

P value

OR (95% CI)

P value

Patients without PCI (n = 430)

    

   Hypothermia

8.24 (4.24 to 16.0)

<0.001

2.13 (1.17 to 3.90)

0.014

   Fibrinolysis

0.52 (0.28 to 0.98)

0.042

0.59 (0.25 to 1.38)

0.223

   Location at home

1.42 (0.92 to 2.20)

0.116

1.59 (0.86 to 2.92)

0.137

   Age <60 years

1.45 (0.89 to 2.36)

0.135

2.25 (1.24 to 4.07)

0.007

   Witnessed OHCA

1.04 (0.64 to 1.68)

0.889

1.33 (0.66 to 2.69)

0.423

   Bystander CPR

3.52 (1.84 to 6.76)

<0.001

1.45 (0.67 to 3.16)

0.35

   VF/pVT as first ECG rhythm

1.96 (1.21 to 3.16)

0.006

2.27 (1.26 to 4.09)

0.006

   Cardiac etiology

0.80 (0.47 to 1.34)

0.391

0.72 (0.36 to 1.50)

0.358

Patients with normothermia (n = 405)

   

   PCI

4.46 (2.26 to 8.80)

<0.001

10.81 (5.86 to 19.93)

<0.001

   Fibrinolysis

0.32 (0.16 to 0.63)

<0.001

0.40 (0.15 to 1.05)

0.064

   Location at home

1.39 (0.90 to 2.17)

0.141

1.44 (0.79 to 2.63)

0.237

   Age <60 years

1.59 (0.98 to 2.58)

0.063

2.04 (1.10 to 3.78)

0.024

   Witnessed OHCA

1.19 (0.73 to 1.93)

0.496

1.97 (0.92 to 4.21)

0.08

   Bystander CPR

2.50 (1.34 to 4.69)

0.004

0.99 (0.44 to 2.24)

0.976

   VF/pVT as first ECG rhythm

2.15 (1.33 to 3.48)

0.002

1.47 (0.79 to 2.73)

0.23

   Cardiac etiology

1.06 (0.62 to 1.83)

0.821

1.37 (0.61 to 3.09)

0.445

All patients (n = 584)

    

   Hypothermia

7.50 (4.12 to 13.65)

<0.001

1.27 (0.79 to 2.03)

0.327

   PCI

3.88 (2.11 to 7.13)

<0.001

5.66 (3.54 to 9.03)

<0.001

   Fibrinolysis

0.39 (0.22 to 0.71)

<0.001

0.63 (9.33 to 1.22)

0.171

   Location at home

1.29 (0.86 to 1.93)

0.223

1.03 (0.66 to 1.63)

0.888

   Age <60 years

1.79 (1.14 to 2.82)

0.012

2.87 (1.83 to 4.49)

<0.001

   Witnessed OHCA

1.31 (0.84 to 2.06)

0.237

1.83 (1.02 to 3.27)

0.042

   Bystander CPR

2.27 (1.26 to 4.08)

0.006

0.72 (0.39 to 1.32)

0.287

   VF/pVT as first ECG rhythm

1.81 (1.17 to 2.80)

0.008

1.61 (1.01 to 2.54)

0.043

   Cardiac etiology

1.0 (0.61 to 1.64)

0.997

1.33 (0.70 to 2.50)

0.385

  1. In contrast to Tables S1 to S6 in Additional file 1, which show detailed backward elimination starting with all candidate variables (step 1) and deleting any that were not significant (up to step 6), this table summarizes the adjusted odds ratio (OR) with 95% confidence interval (95% CI) from the respective step before deleting in the next step. Backwards stepwise binary logistic regression analysis was performed for 24-hour survival and good neurological outcome taking into account the following confounding factors: age, location of out-of-hospital cardiac arrest (OHCA), presumed etiology, bystander cardiopulmonary resuscitation (CPR), witnessing, first electrocardiogram (ECG) rhythm (ventricular fibrillation (VF)/pulseless ventricular tachycardia (pVT)), and systemic fibrinolysis. We performed three approaches for subgroup analysis by evaluating: hypothermia as an independent predictor in patients without any coronary intervention (n = 430), percutaneous coronary intervention (PCI) as an independent predictor in patients without hypothermia (n = 405), and the impact of both hypothermia and PCI in all patients (n = 584).
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