Allele or haplotype * | ARDS | No ARDS |
P
â€
OR (95% CI) |
P
‡
OR (95% CI) |
P
§
OR (95% CI) |
---|
SFTPD
| N = 52 | N = 1,312 | Â | Â | Â |
C
| 29 (55.8) | 510 (38.9) | 0.015 1.98 (1.09-3.63) | 0.032 1.92 (1.06-3.48) | 0.050 1.79 (1.00-3.20) |
SFTPA1
| N = 52 | N = 1,312 | Â | Â | Â |
6A
| 8 (15.4) | 82 (6.3) | 0.018|| 2.73 (1.07-6.11) | 0.004 3.89 (1.56-9.72) | 0.022 2.64 (1.15-6.08) |
SFTPA2
| N = 52 | N = 1,312 | Â | Â | Â |
1A
| 7 (13.5) | 140 (10.7) | 0.524 1.30 (0.49-2.98) | - | - |
1A
10
| 1 (1.9) | 22 (1.7) | 0.594|| 1.15 (0.03-7.40) | - | - |
SFTPA1-SFTPA2
| N = 52 | N = 1,312 | Â | Â | Â |
6A-1A
| 7 (13.5) | 51 (3.9) | 0.005§ 3.85 (1.39-9.15) | 0.0006 5.83(2.12-16.04) | 0.012 3.16 (1.28-7.80) |
6A
3
-1A
1
| 5 (9.6) | 161 (12.3) | 0.566 0.76 (0.23-1.94) | - | - |
- For allelic and haplotypic frequencies values are the number of chromosomes (%). Only relevant haplotypes are shown. CAP: Community Acquired Pneumonia; ARDS: Acute Respiratory Distress Syndrome.
- *Haplotypes for SFTPA1 and SFTPA2, resulting from the different combinations of the three SNPs (Single nucleotide polymorphisms) studied at each gene, are denoted using the conventional nomenclature [15].
- †P value for the bivariate comparison.
- ‡P value for multivariate analysis, including the variables age, gender, hospital of origin and co-morbidities. For those bivariate comparisons that resulted in non-significant differences, multivariate analysis were not calculated.
- §P value for multivariate analysis, including the variables hospital of origin, PSI (Pneumonia Severity Index) and pathogen.
- ||P-value by Fischer exact test.