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Table 6 Predisposition to ARDS related to SFTPD alleles and to SFTPD, SFTPA1 and SFTPA2 haplotypes in patients with CAP

From: Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study

Allele or haplotype *

ARDS

No ARDS

P †

OR (95% CI)

P ‡

OR (95% CI)

P §

OR (95% CI)

SFTPD

N = 52

N = 1,312

   

C

29 (55.8)

510 (38.9)

0.015

1.98 (1.09-3.63)

0.032

1.92 (1.06-3.48)

0.050

1.79 (1.00-3.20)

SFTPA1

N = 52

N = 1,312

   

6A

8 (15.4)

82 (6.3)

0.018||

2.73 (1.07-6.11)

0.004

3.89 (1.56-9.72)

0.022

2.64 (1.15-6.08)

SFTPA2

N = 52

N = 1,312

   

1A

7 (13.5)

140 (10.7)

0.524 1.30 (0.49-2.98)

-

-

1A 10

1 (1.9)

22 (1.7)

0.594||

1.15 (0.03-7.40)

-

-

SFTPA1-SFTPA2

N = 52

N = 1,312

   

6A-1A

7 (13.5)

51 (3.9)

0.005§

3.85 (1.39-9.15)

0.0006

5.83(2.12-16.04)

0.012

3.16 (1.28-7.80)

6A 3 -1A 1

5 (9.6)

161 (12.3)

0.566

0.76 (0.23-1.94)

-

-

  1. For allelic and haplotypic frequencies values are the number of chromosomes (%). Only relevant haplotypes are shown. CAP: Community Acquired Pneumonia; ARDS: Acute Respiratory Distress Syndrome.
  2. *Haplotypes for SFTPA1 and SFTPA2, resulting from the different combinations of the three SNPs (Single nucleotide polymorphisms) studied at each gene, are denoted using the conventional nomenclature [15].
  3. †P value for the bivariate comparison.
  4. ‡P value for multivariate analysis, including the variables age, gender, hospital of origin and co-morbidities. For those bivariate comparisons that resulted in non-significant differences, multivariate analysis were not calculated.
  5. §P value for multivariate analysis, including the variables hospital of origin, PSI (Pneumonia Severity Index) and pathogen.
  6. ||P-value by Fischer exact test.