Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study

Table 5 Predisposition to MODS related to SFTPD alleles and to SFTPD, SFTPA1 and SFTPA2 haplotypes in patients with CAP

Allele or haplotype*	MODS	No MODS	P ^† OR (95% CI)	P ^‡ OR (95% CI)	P ^§ OR (95% CI)
SFTPD	N = 178	N = 1,186
C	85 (47.8)	454 (38.4)	0.016 1.47 (1.06-2.05)	0.002 1.68 (1.20-2.35)	0.043 1.46 (1.01-2.10)
SFTPA1	N = 178	N = 1,186
6A	14 (7.9)	76 (6.4)	0.465 1.25 (0.64-2.29)	-	-
SFTPA2	N = 178	N = 1,186
1A	32 (18.0)	115 (9.7)	0.0009 2.04 (1.28-3.17)	0.0004 2.29 (1.45-3.62)	0.002 2.21 (1.34-3.65)
1A ¹⁰	8 (4.5)	15 (1.3)	0.006^\|\| 3.67 (1.33-9.38)	0.033 2.70 (1.08-6.76)	0.033 2.98 (1.09-8.10)
SFTPA1-SFTPA2	N = 178	N = 1,186
6A-1A	12 (6.7)	46 (3.9)	0.078 1.79 (0.85-3.52)	-	-
6A ³ -1A ¹	13 (7.3)	153 (12.9)	0.033 0.53 (0.27-0.97)	0.115 0.62 (0.34-1.13)	0.097 0.58 (0.31-1.10)

For allelic and haplotypic frequencies values are the number of chromosomes (%). Only relevant haplotypes are shown. CAP: Community Acquired Pneumonia; MODS: Multi-organ Dysfunction Syndrome.
*Haplotypes for SFTPA1 and SFTPA2, resulting from the different combinations of the three SNPs (Single nucleotide polymorphisms) studied at each gene, are denoted using the conventional nomenclature [15].
^†P-value for the bivariate comparison.
^‡P-value for multivariate analysis, including the variables age, gender, hospital of origin and co-morbidities. For those bivariate comparisons that resulted in non-significant differences, multivariate analysis were not calculated.
^§P-value for multivariate analysis, including the variables hospital of origin, PSI (Pneumonia Severity Index) and pathogen.
^||P-value by Fischer exact test.

ISSN: 1364-8535