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Table 2 Comparison of haplotypes of SFTPA1 and SFTPA 2 between patients with CAP and controls

From: Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study

Haplotype *

Controls

N = 1,538

CAP

N = 1,364

P †

OR (95% CI)

Haplotype effect

P ‡

OR (95% CI)

SFTPA1

     

6A (CCC)

75 (4.9)

90 (6.6)

0.047 1.38 (0.99-1.92)

Dominant

0.058 1.37 (0.99-1.91)

    

Recessive

0.347§ 3.39 (0.27-178.36)

6A2 (TGC)

934 (60.7)

745 (54.0)

0.0009 0.78 (0.67-0.91)

Dominant

0.172 0.83 (0.64-1.08)

    

Recessive

0.0002 0.66 (0.53-0.82)

6A3 (TCC)

362 (23.5)

343 (25.1)

n.s.

Dominant

0.004 1.37 ( (1.11-1.69)

    

Recessive

0.146 1.35 (0.90-2.18)

6A4 (TCT)

128 (8.3)

141 (10.3)

0.062 1.27 (0.98-1.65)

Dominant

0.068 1.28 (0.98-1.68)

    

Recessive

0.726§ 1.66 (0.32-10.76)

6A5 (CCT)

4 (0.3)

7 (0.5)

n.s.

Dominant

0.107 2.56 (0.78-8.34)

    

Recessive

n.a.

6A12 (TGT)

26 (1.7)

29 (2.1)

n.s.

Dominant

0.315 1.32 (0.77-2.28)

    

Recessive

n.a.

6A15 (CGC)

9 (0.6)

9 (0.7)

n.s.

Dominant

0.996 1.00 (0.39-2.61)

    

Recessive

n.a.

SFTPA2

     

1A (CCC)

134 (8.7)

147 (10.8)

n.s.

Dominant

0.050 1.31 (1.00-1.71)

    

Recessive

0.80 1.13 (0.45-2.86)

1A0(AGC)

911 (59.2)

729 (53.4)

0.002 0.79 (0.68-0.92)

Dominant

0.004 0.68 (0.52-0.88)

    

Recessive

0.025 0.78 (0.62-0.97)

1A1(CGA)

219 (14.2)

222 (16.3)

n.s.

Dominant

0.544 1.14 (0.91-1.44)

    

Recessive

0.076 1.91 (0.925-3.93)

1A2(CGC)

188 (12.2)

164 (12.0)

n.s.

Dominant

0.806 0.97 (0.76-1.24)

    

Recessive

0.863 1.06 (0.53-2.12)

1A3(AGA)

61 (4.0)

46 (3.4)

n.s.

Dominant

0.557 0.89 (0.59-1.33)

    

Recessive

n.a.

1A7(ACC)

21 (1.4)

32 (2.3)

0.049 1.74 (0.96-3.18)

Dominant

0.031 1.88 (1.05-3.36)

    

Recessive

1.00§ 0.56 (0.01-10.84)

1A10(CCA)

4 (0.3)

23 (1.7)

0.00007 6.58 (2.24-26.22)

Dominant

0.00006 6.68 (2.30-19.40)

    

Recessive

n.a.

1A13(ACA)

0

1 (0.1)

n.s.

Dominant

n.a.

    

Recessive

n.a.

  1. Frequency values are the number of chromosomes (%). CAP, Community-acquired pneumonia; n.s., non-significant; n.a., not assessable.
  2. *Haplotypes for SFTPA1 and SFTPA2, resulting from the different combinations of the three SNPs (Single nucleotide polymorphisms) studied at each gene, are denoted using the conventional nomenclature [15].
  3. †Uncorrected P-value for the bivariate comparison of haplotypes.
  4. ‡Uncorrected P-value for the bivariate comparison of genopytes. For the dominant haplotype effect, individuals homozygous or heterozygous for the allele of interest were defined as 1, and individuals without the haplotype were defined as 0. For the recessive haplotype effect, individuals homozygous for the haplotype of interest were defined as 1, with all others defined as 0.
  5. §P-value by Fischer exact test.