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Table 1 Comparison of SNPs from SFTPD, SFTPA 1 and SFTPA2 between patients with CAP and controls

From: Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study

   

Alleles comparison

Genotypes comparison †

 

Controls (N = 769)

CAP (N = 682)

P *

OR (95% CI)

P *

OR (95% CI)

SFTPD aa11 rs721917

  

T vs C

Dominant

T/T

269 (35.0)

272 (39.9)

  

0.681

0.95 (0.73 to 1.1.23)

T/C

361 (46.9)

281 (41.2)

0.266

1.09 (0.94to 1.27)

Recessive

C/C

139 (18.1)

129 (18.9)

  

0.054

1.23 (1.00 to 1.53)

SFTPA1 aa19 rs1059047

  

T vs C

Dominant

T/T

680 (88.4)

582 (85.3)

  

0.193‡

0.22 (0.00 to 2.24)

T/C

88 (11.4)

96 (14.1)

0.056

0.75 (0.56 to 1.02)

Recessive

C/C

1 (0.001)

4 (0.006)

  

0.081

0.76 (0.56 to 1.04)

SFTPA1 aa50 rs1136450

  

G vs C

Dominant

G/G

320 (41.6)

232 (34.0)

  

0.060

0.77 (0.59 to 1.01)

G/C

330 (42.9)

319 (46.8)

0.002

0.79 (0.68 to 0.92)

Recessive

C/C

119 (15.5)

131 (19.2)

  

0.003

0.72 (0.58 to 0.90)

SFTPA1 aa219 rs4253527

  

C vs T

Dominant

C/C

620 (80.6)

508 (74.5)

  

0.710

1.24 (0.39 to 3.94)

C/T

142 (18.5)

169 (24.8)

0.012

0.75 (0.59 to 0.95)

Recessive

T/T

7 (0.9)

5 (0.7)

  

0.005

0.70 (0.55 to 0.90)

SFTPA2 aa9 rs1059046

  

A vs C

Dominant

A/A

323 (42.0)

245 (35.9)

  

0.010

0.68 (0.51 to 0.91)

A/C

349 (45.4)

318 (46.6)

0.003

0.79 (0.68 to 0.92)

Recessive

C/C

97 (12.6)

119 (17.4)

  

0.018

0.77 (0.63 to 0.96)

SFTPA2 aa91 rs17886395

  

G vs C

Dominant

G/G

623 (81.0)

501 (73.5)

  

0.110

0.58 (0.29 to 1.14)

G/C

133 (17.3)

158 (23.2)

0.0002

0.66 (0.52 to 0.82)

Recessive

C/C

13 (1.7)

23 (3.4)

  

0.001

0.65 (0.51 to 0.83)

SFTPA2 aa223 rs1965708

  

C vs A

Dominant

C/C

503 (65.4)

419 (61.4)

  

0.151

0.66 (0.38 to 1.17)

C/A

244 (31.7)

234 (34.3)

0.071

0.85 (0.70 to 1.02)

Recessive

A/A

22 (2.9)

29 (4.3)

  

0.117

0.84 (0.68 to 1.04)

  1. Frequency values are the number of individuals (%). SNPs: Single nucleotide polymorphisms; CAP: Community-acquired pneumonia.
  2. * Uncorrected P-value for the bivariate comparison of alleles.
  3. † Uncorrected P-value for the bivariate comparison of genopytes. For the dominant allele effect, individuals homozygous for the more frequent allele or those heterozygous for both alleles were defined as 1, and individuals homozygous for the minor allele were defined as 0. For the recessive allele effect, individuals homozygous for the more frequent allele were defined as 1, with all others defined as 0.
  4. ‡P-value by Fischer exact test.
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