Table 2 Data compiled from animal studies in inflammation and sepsis
From: Clinical review: Adiponectin biology and its role in inflammation and critical illness
Year | Reference | Data |
|---|---|---|
2002 | Maeda et al. [24] | Delayed clearance of free fatty acids and increased plasma TNF-α in adiponectin KO mice |
2006 | Tsuchihashi et al. [59] | Rat CLP model shows that adiponectin negatively correlates with plasma endotoxin and TNF-α |
2006 | Pini et al. [61] | No significant difference in the inflammatory response generated by LPS and concanavalin A administration to wild-type and adiponectin KO mice |
2008 | Teoh et al. [60] | Mouse CLP and thioglycollate-induced peritonitis produces a reduction in survival of adiponectin KO mice |
2008 | Pini et al. [62] | Reduction in circulating adiponectin levels during acute inflammation secondary to zymosan-induced peritonitis in wild-type mice. Adiponectin does not appear to influence the inflammatory response |
2009 | Uji et al. [56] | Mouse CLP model showed adiponectin KO mice are more susceptible to polymicrobial sepsis; higher circulating endotoxin in adiponectin KO mice; PPAR-γ administration prior to CLP improved mortality in wild type, but not adiponectin KO mice |
2009 | Leuwer et al. [80] | Following injection of LPS in mice, adiponectin mRNA levels fell in white adipose tissue (epididymal, perirenal and subcutaneous), MCP-1 and IL-6 mRNA rose in all three depots and TNF-α mRNA rose in epididymal and perirenal sites |
2010 | Uji et al. [57] | Adiponectin KO and wild-type mice were subjected to CLP. KO mice showed higher circulating levels of pro-inflammatory cytokines and greater evidence of hepatic injury than wild-type mice |