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Table 2 Comparison of patients with different measured creatinine clearance (CLCR)

From: Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

  ClCR < 120 (n= 178) ClCR > 120 (n= 106) P* ClCR < 60 (n= 63) ClCR > 60 (n= 221) P #
Age (yr) 56 ± 18 40 ± 16 < 0.0001 63 ± 15 46 ± 18 < 0.0001 < 0.0001
Weight (Kg) 74 ± 17 74 ± 14 NS 73 ± 19 74 ± 15 NS NS
Sex (F/M) 64/114 24/82 0.03 35/28 161/60 NS 0.0032
Ideal body weight (Kg) 69 ± 12 72 ± 10 0.01 65 ± 11 71 ± 11 0.0002 < 0.0001
SAPS 2 50 ± 15 43 ± 14 0.0002 54 ± 14 45 ± 15 < 0.0001 < 0.0001
Serum creatinine (μmol L-1) 76 ± 24 67 ± 19 0.0001 85 ± 25 69 ± 20 < 0.0001 < 0.0001
Diuresis/24H 2,400 ± 100 2,800 ± 1200 < 0.0001 584 ± 224 1,418 ± 694 0.0019 < 0.0001
Measured creatinine clearance (mL min-1 .1.73 m-2) 74 ± 30 166 ± 50 < 0.0001 43 ± 11 127 ± 50 < 0.0001 < 0.0001
Simplified MDRD (mL minute-1 1.73 m-2) 96 ± 39 119 ± 45 < 0.0001 81 ± 34 112 ± 43 < 0.0001 < 0.0001
Cockcroft-Gault (mL minute-1 1.73 m-2) 98 ± 39 130 ± 34 0.0005 80 ± 39 118 ± 36 < 0.0001 < 0.0001
Robert (mL minute-1 1.73 m-2) 72 ± 23 94 ± 23 < 0.0001 59 ± 2 85 ± 2 < 0.0001 < 0.0001
PT b/NPT a 65/113 79/27 < 0.0001 15/48 129/92 < 0.0001 < 0.0001
  1. All data are expressed as ratio or mean ± SD.
  2. * The P-values correspond to comparison between subgroup with CLCR greater than 120 mL minute-1 1.73 m-2 versus subgroup with CLCR lower than 120 mL minute-1 1.73 m-2.
  3. # The P-values correspond to comparaison between subgroup with CLCR greater than 60 mL minute-1 1.73 m-2 versus subgroup with CLCR lower than 60 mL minute-1 1.73 m-2.
  4. § The P-values correspond to comparison between less than 60 mL minute-1 1.73 m-2 more than 120 mL minute-1 1.73 m-2.
  5. a NPT = non-polytrauma patients.
  6. b PT = polytrauma patients.