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Table 2 Comparison between hospital survivors and nonsurvivorsa

From: Hormonal status in protracted critical illness and in-hospital mortality

Patient demographics, N= 102 (100%)

Hospital survivors (n= 78)

Hospital nonsurvivors (n= 24)

P value b

OR (95% CI) c

Women, n (%)

24 (30.8)

13 (54.2)

0.05

2.7 (0.97 to 6.8)

Median age, yr (IQR)

62 (47 to 77)

69 (58 to 80)

0.13

 

From admission to awakening (day 1)

    

   Mean blood glucosed, mM/l (IQR)

7.6 (6.8 to 8.6)

8.3 (7.2 to 9.7)

0.07

1.2 (0.95 to 1.4)

Women

8.0 (7.0 to 8.7)

9.4 (7.8 to 11.1)

0.03

1.5 (0.98 to 2.2)

Men

7.4 (6.7 to 8.6)

7.2 (6.7 to 8.7)

0.89

 

At awakening (day 1)

    

   Median SAPS II (IQR)

28 (21 to 34)

35 (29 to 41)

0.007

1.1 (1.0 to 1.1)

   Median FSHe, mIU/ml (IQR)

    

Women

2.9 (0.75 to 17.9)

1.6 (0.68 to 4.7)

0.41

 

Men

3.9 (1.9 to 7.6)

3.8 (1.6 to 6.5)

0.93

 

   Median LHe, mIU/ml (IQR)

    

Women

0.35 (0.2 to 3.0)

0.21 (0.21 to 1.2)

0.61

 

Men

4.35 (2.2 to 6.5)

6.9 (0.63 to 13)

0.56

 

   Median prolactin, ng/ml (IQR)

9.5 (5.2 to 16)

8.3 (5.1 to 15)

0.54

 

   Median estradiole, pg/ml (IQR)

    

Women

10 (10 to 28)

10 (10 to 12)

0.82

 

Men

14.5 (10 to 23)

10 (10 to 24)

0.79

 

   Median testosteronee, ng/ml (IQR)

    

Women

0.09 (0.07 to 0.18)

0.07 (0.07 to 0.16)

0.81

 

Men

0.78 (0.35 to 1.70)

0.63 (0.43 to 1.1)

0.57

 

   Median cortisolf, ng/ml (IQR)

16.0 (12.0 to 23.0)

23.0 (18.5 to 34.5)

0.01

4.3 (1.5 to 12.1)

Women

15.5 (12.0 to 25.0)

23.0 (20.0 to 25.0)

  

Men

16.0 (12.0 to 23.0)

22.0 (14.0 to 41.5)

  

   Median DHEAe, ng/ml (IQR)

    

Women

0.30 (0.30 to 0.66)

0.30 (0.30 to 0.89)

0.50

 

Men

0.59 (0.30 to 1.80)

0.30 (0.30 to 0.45)

0.01

0.2 (0.04 to 0.97)

   Median DHEASe, ng/ml (IQR)

    

Women

262 (107 to 469)

366 (79 to 580)

0.86

 

Men

486 (184 to 1,141)

198 (100 to 310)

0.04

0.2 (0.03 to 0.8)

   Median progesterone, ng/ml (IQR)

    

Women

0.23 (0.05 to 0.29)

0.24 (0.04 to 0.69)

0.49

 

   Median SH (%)

57 (73%)

18 (75%)

1.00

 

   Median PH (%)

    

Men

19 (35%)

6 (55%)

0.31

 

   Median TSH, mIU/ml (IQR)

1.25 (0.52 to 2.35)

1.34 (0.74 to 2.12)

0.68

 

   Median IGF-1, ng/ml (IQR)

78 (56 to 112)

65 (46 to 70)

0.007

0.2 (0.07 to 0.6)

Women

73.5 (50.5 to 113.5)

59.5 (57.5 to 69.0)

  

Men

81 (59 to 111)

65.0 (50.0 to 73.0)

  
  1. aSAPS, Simplified Acute Physiology Score II [15]; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate; FSH, follicle-stimulating hormone; LH, luteinizing hormone; TSH, thyroid-stimulating hormone; IGF-1, insulin-like growth factor 1; SH secondary hypogonadism; PH, primary hypogonadism; IQR, interquartile range; OR, odds ratio; 95% CI, 95% confidence interval; bP values were derived from performing the Mann-Whitney U test or Fisher's exact test as appropriate; cOR and 95% CI were estimated by using exact logistic regression models; dORs estimated after dichotomization on median value; eassessed in 85 patients, including 56 men and 29 postmenopausal women, among whom 11 men and 11 women died in the hospital, respectively; fplasma cortisol levels of 83 patients were taken into account in the analysis; the other 19 patients were still being treated with hydrocortisone at the time the blood sample was taken and thus were excluded from the cortisol measurement.
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Critical Care

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