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Table 2 Laboratory parameters on admission and at 24 and 48 hours

From: Pathophysiological aspects of hyperglycemia in children with meningococcal sepsis and septic shock: a prospective, observational cohort study

 

Shock non-survivors

Shock survivors

Sepsis survivors

 

T 0

T 0

T 24 g

T 48 g

T 0

T 24

 

(n = 10)

(n = 57)

(n = 48)

(n = 36)

(n = 11)

(n = 6)

Glucose, mmol/L

4.9a,b

7.2,b,c

6.7

5.9

8.8a,c

6.6

 

(2.7-7.0)

(5.3-9.0)

(5.9-7.8)

(5.3-6.6)

(7.5-10.5)

(4.7-7.1)

Insulin, pmol/L

<35a,b

101c

111

89

104c

136

 

(<35-57)

(35-197)

(71-169)

(61-157)

(52-226)

(51-236)

C-peptide, nmol/L

-

1.1

2.0

1.5

1.0

1.7

  

(0.6-2.7)

(1.0-3.0)

(1.0-1.9)

(0.5-1.8)

(1.0-2.6)

Cortisol but not glucocorticoids, nmol/L

615a,b

954c

603

554

1,140c

447

 

(510-930)

(713-1,241)

(430-1,409)

(501-927)

(1,066-1,409)

(263-657)

FFAs, mmol/L

0.3

0.8

0.6

0.3

0.6

0.5

 

(0.2-0.5)

(0.5-1.1)

(0.4-0.8)

(0.3-0.6)

(0.5-0.7)

(0.4-0.7)

Lactate, mmol/L

6.8d,e

3.7e,f

2.0

1.6

2.1d,f

0.8

 

(5.1-8.0)

(2.6-5.4)

(1.5-2.8)

(1.2-2.3)

(1.6-2.7)

(0.7-0.9)

CRP, mg/L

34a,e

89c

229

223

75f

236

 

(23-41)

(59-131)

(181-274)

(159-301)

(36-191)

(195-273)

IL-6, pg/mL

120 × 104d,f

3.5 × 104e,f

0.02 × 104b

0.01 × 104

0.04 × 104d,f

17a

 

(70-160 × 104)

(1-16 × 104)

(0.01-0.2 × 104)

(0.003-0.03 × 104)

(82-1 × 104)

(<10-0.02 × 104)

TNF-α, pg/mL

42d

6f

4

-

-

3

 

(20-127)

(<5-10.5)

(1-12)

  

(1-10)

  1. Children who received steroids before or on admission were excluded from determination of median cortisol levels. Data are expressed as median (25th-75th percentile). aCompared with shock survivors, P < 0.05; bcompared with sepsis survivors, P < 0.05; ccompared with shock non-survivors, P < 0.05; dcompared with shock survivors, P < 0.001; ecompared with sepsis survivors, P < 0.001; fcompared with shock non-survivors, P < 0.001; gone patient with insulin therapy was excluded. CRP, C-reactive protein; FFA, free fatty acid; IL-6, interleukin-6; T0, on admission; T24, at 24 hours after admission; T48, at 48 hours after admission; TNF-α, tumor necrosis factor-alpha.