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Table 3 NRI and IDI for assessing improvement in model performance after adding biomarkers to APACHE-II score

From: Usefulness of N-terminal pro-brain natriuretic peptide and C-reactive protein to predict ICU mortality in unselected medical ICU patients: a prospective, observational study

 

NRI

Z value for NRI

P-value for NRI

IDI

Z value for NRI

P-value for NRI

APACHE-II score + log(NT-proBNP)

16.6%

2.982

0.003

6.6%

2.680

0.007

APACHE-II score + log(CRP)

12.1%

2.216

0.026

5.6%

2.267

0.023

APACHE-II score + log(NT-proBNP) +log(CRP)

17.9%

3.042

0.002

7.5%

3.036

0.002

  1. APACHE II score, Acute Physiology and Chronic Health Evaluation II score; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; IDI, integrated discrimination improvement; NRI, Net reclassification improvement; N-terminal pro-brain natriuretic peptide; NT-proBNP